| Gene Symbol | HLA-DMA |
|---|---|
| Entrez Gene | 3108 |
| Alt Symbol | D6S222E, DMA, HLADM, RING6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DM alpha |
| Other Description | HLA class II histocompatibility antigen, DM alpha chain|MHC class II antigen DMA|class II histocompatibility antigen, M alpha chain|really interesting new gene 6 protein |
| Swissprots | P28067 Q29639 Q29640 |
| Accessions | AAA56993 AAA56994 AHW47929 AHW47946 AHW47963 AHW47980 BAA31432 CAA54169 CAA54170 CAA60781 EAX03658 EAX03659 EAX03660 P28067 AA649861 AK291858 BAF84547 AK298081 BAH12721 AU100342 BC011447 AAH11447 BC026279 AAH26279 CR450324 CAG29320 DQ892839 ABM83765 DQ896086 ABM87085 X62744 CAA44606 NM_006120 NP_006111 |
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}. |
| Subcellular Location | Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. |
| Top Pathways | Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection |