| Gene Symbol |
Cenpa
|
| Entrez Gene |
12615
|
| Alt Symbol |
Cenp-A
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
centromere protein A
|
| Other Description |
centromere autoantigen A|centrosomin A|histone H3-like centromeric protein A
|
| Swissprots |
O35216 Q545C9
|
| Accessions |
AAC39958 EDL37283 EDL37284 EDL37285 EDL37286 EDL37287 EDL37288 O35216 AA016357 AF012709 AAC39957 AK010718 BAB27140 AK011399 BAB27591 AK036511 AK040313 AK041138 AK053763 BAC35512 AK080283 AK089033 BAC40710 AK182390 AK184358 BC011038 AAH11038 BC012280 BQ748418 BY136144 XM_011240699 XP_011239001 NM_001302129 NP_001289058 NM_001302130 NP_001289059 NM_001302131 NP_001289060 NM_001302132 NP_001289061 NM_007681 NP_031707 NR_126074
|
| Function |
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (By similarity). {ECO:0000250}.
|