| Gene Symbol |
Fkbp8
|
| Entrez Gene |
14232
|
| Alt Symbol |
38kDa, FKBP-38, FKBP-8, Fkbp38
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
FK506 binding protein 8
|
| Other Description |
38 kDa FK506-binding protein|38 kDa FKBP|FK506-binding protein 38|FK506-binding protein 8|FKBPR38|PPIase FKBP8|mFKBP38|peptidyl-prolyl cis-trans isomerase FKBP8|rotamase
|
| Swissprots |
O35465 Q811R4 Q8C2F0 Q3UK86 Q811M7 Q99L93 Q6GTX9
|
| Accessions |
AAO27795 EDL28840 EDL28841 EDL28842 O35465 AB154247 BAI44632 AF030635 AAB86422 AK040736 AK088739 BAC40541 AK146122 BAE26916 AK152198 BAE31027 AK153000 AK158155 AK165281 BAE38118 AK167663 BAE39713 AK170993 AK177460 AK177591 AK178628 AK179469 AK180952 AK182349 AK184741 AK188492 AK189147 AK189244 AK190318 AK190969 AK192821 AK197324 AK197498 AK205574 AK206245 AK207414 AK208969 AK209719 AK211059 AK212094 AK212129 AK213138 AK214360 AK216136 AK218022 AY225340 AAO39021 AY278608 AAQ84562 BB842097 BC003739 AAH03739 BC027808 AAH27808 DV644627 XM_006509556 XP_006509619 XR_379034 NM_001111066 NP_001104536 NM_001199631 NP_001186560 NM_010223 NP_034353
|
| Function |
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000269|PubMed:15105374}; Single-pass membrane protein {ECO:0000269|PubMed:15105374}; Cytoplasmic side {ECO:0000269|PubMed:15105374}.
|
| Tissue Specificity |
Detected throughout the embryonic body, in caudal neural tube, limbs and head. Detected in adult retina, brain, heart, kidney, liver, pancreas, lung, testis and urinary bladder (at protein level). Detected in adult brain, kidney, liver, testis and trigeminal nerve, and in embryo. Detected at lower levels in lung, spleen, heart and ovary. Widely expressed in forebrain. Detected in the Purkinje cell layer in the cerebellum and in hippocampus neurons. {ECO:0000269|PubMed:10197430, ECO:0000269|PubMed:14667822, ECO:0000269|PubMed:15105374}.
|
