Gene Symbol | TRH |
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Entrez Gene | 7200 |
Alt Symbol | Pro-TRH, TRF |
Species | Human |
Gene Type | protein-coding |
Description | thyrotropin-releasing hormone |
Other Description | TSH-releasing factor|pro-thyrotropin-releasing hormone|prothyroliberin|protirelin|thyrotropin releasing hormone|thyrotropin-releasing factor |
Swissprots | Q2TB83 B2R8R1 P20396 |
Accessions | AAA36480 EAW79229 P20396 AK313473 BAG36258 AW205952 BC069375 AAH69375 BC074888 AAH74888 BC074889 AAH74889 BC110515 AAI10516 BC110516 AAI10517 BE670731 DA515022 DA526260 NM_007117 NP_009048 |
Function | Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. {ECO:0000269|PubMed:19825978}. |
Subcellular Location | Secreted. |
Tissue Specificity | Hypothalamus. Expressed in the hair follicle epithelium (at protein level). {ECO:0000269|PubMed:19825978}. |
TRH CRISPR/Cas9 KO Plasmid (h) - sc-405685 from Santa Cruz Biotechnology
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TRH HDR Plasmid (h) - sc-405685-HDR from Santa Cruz Biotechnology
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TRH Double Nickase Plasmid (h) - sc-405685-NIC from Santa Cruz Biotechnology
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TRH Double Nickase Plasmid (h2) - sc-405685-NIC-2 from Santa Cruz Biotechnology
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TRH CRISPR Activation Plasmid (h) - sc-405685-ACT from Santa Cruz Biotechnology
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TRH CRISPR Activation Plasmid (h2) - sc-405685-ACT-2 from Santa Cruz Biotechnology
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TRH Lentiviral Activation Particles (h) - sc-405685-LAC from Santa Cruz Biotechnology
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TRH Lentiviral Activation Particles (h2) - sc-405685-LAC-2 from Santa Cruz Biotechnology
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TRH siRNA (h) - sc-77977 from Santa Cruz Biotechnology
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TRH shRNA Plasmid (h) - sc-77977-SH from Santa Cruz Biotechnology
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TRH shRNA (h) Lentiviral Particles - sc-77977-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21947 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21947 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05774 from Sigma-Aldrich
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TRH siRNA (Human) - CRH4939 from Cohesion Biosciences
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TRH - MBS8200198 from MyBioSource
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shRNA set against Human TRH (NM_007117.3) - SHH434260 from Creative biogene
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Human TRH siRNA - orb265441 from Biorbyt
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TRH shRNA Plasmid (Human) - CHH4939 from Cohesion Biosciences
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TRH miRNA 3'UTR clone - MiUTR3H-13059 from Creative biogene
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