| Gene Symbol |
Enpp1
|
| Entrez Gene |
18605
|
| Alt Symbol |
4833416E15Rik, AI428932, C76301, CD203c, E-NPP1, Ly-41, M6S1, NPP1, Npps, PC-1, Pca, Pca-1, Pdnp1, ttw, twy
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ectonucleotide pyrophosphatase/phosphodiesterase 1
|
| Other Description |
1 ectonucleotide pyrophosphatase/phosphodiesterase 1|E-NPP 1|ectonucleotide pyrophosphatase/phosphodiesterase family member 1|lymphocyte antigen 41|phosphodiesterase I/nucleotide pyrophosphatase 1|phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1|plasma-cell membrane glycoprotein PC-1|tiptoe walking
|
| Swissprots |
Q924C4 P06802 Q542E9
|
| Accessions |
EDL04784 EDL04785 EDL04786 EDL04787 P06802 AF339910 AAK84174 AI428932 AK014707 AK029600 AK035402 AK036952 AK041894 BAE43316 AK088857 BAC40616 AK145233 AK164619 AK211377 BC050011 BC160371 AAI60371 J02700 AAA39893 M12552 AAA39892 XM_006512597 XP_006512660 XM_006512598 XP_006512661 XM_006512599 XP_006512662 XM_006512600 XP_006512663 NM_001308327 NP_001295256 NM_001308329 NP_001295258 NM_008813 NP_032839
|
| Function |
Appears to modulate insulin sensitivity (By similarity). By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. {ECO:0000250, ECO:0000269|PubMed:1647027, ECO:0000269|PubMed:9662402}.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side (By similarity). The proteolytically processed form is secreted. {ECO:0000250}.
|
| Tissue Specificity |
Selectively expressed on the surface of antibody-secreting cells.
|
| Top Pathways |
Purine metabolism, Nicotinate and nicotinamide metabolism, Riboflavin metabolism, Pantothenate and CoA biosynthesis, Starch and sucrose metabolism
|