| Gene Symbol | DYNLT1 |
|---|---|
| Entrez Gene | 6993 |
| Alt Symbol | CW-1, TCTEL1, tctex-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynein, light chain, Tctex-type 1 |
| Other Description | T-complex testis-specific protein 1 homolog|dynein light chain Tctex-type 1|t-complex-associated-testis-expressed 1-like 1 |
| Swissprots | Q5VTU4 Q15763 P63172 |
| Accessions | EAW47655 EAW47656 EAW47657 EAW47658 EAW47659 P63172 AK026669 AK315601 BAG37971 BC029412 AAH29412 BC105588 AAI05589 BU675683 CR456931 CAG33212 D50663 BAA09317 DN915418 DQ892606 ABM83532 DQ892607 ABM83533 DQ895846 ABM86772 DQ895847 ABM86773 EU862237 ACF74976 HY017024 HY171700 U56255 AAB03318 NM_001291602 NP_001278531 NM_001291603 NP_001278532 NM_006519 NP_006510 |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. {ECO:0000269|PubMed:18647839}. |
| Subcellular Location | Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}. |
| Tissue Specificity | Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level). {ECO:0000269|PubMed:14583445}. |
Tctex1 CRISPR/Cas9 KO Plasmid (h) - sc-402886 from Santa Cruz Biotechnology
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Tctex1 HDR Plasmid (h) - sc-402886-HDR from Santa Cruz Biotechnology
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Tctex1 Double Nickase Plasmid (h) - sc-402886-NIC from Santa Cruz Biotechnology
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Tctex1 Double Nickase Plasmid (h2) - sc-402886-NIC-2 from Santa Cruz Biotechnology
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Tctex1 CRISPR Activation Plasmid (h) - sc-402886-ACT from Santa Cruz Biotechnology
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Tctex1 CRISPR Activation Plasmid (h2) - sc-402886-ACT-2 from Santa Cruz Biotechnology
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Tctex1 Lentiviral Activation Particles (h) - sc-402886-LAC from Santa Cruz Biotechnology
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Tctex1 Lentiviral Activation Particles (h2) - sc-402886-LAC-2 from Santa Cruz Biotechnology
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Tctex1 siRNA (h) - sc-43319 from Santa Cruz Biotechnology
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Tctex1 shRNA Plasmid (h) - sc-43319-SH from Santa Cruz Biotechnology
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Tctex1 shRNA (h) Lentiviral Particles - sc-43319-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7592 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7592 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02832 from Sigma-Aldrich
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DYNLT1 siRNA (Human) - CRH4775 from Cohesion Biosciences
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DYNLT1 - MBS8235737 from MyBioSource
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shRNA set against Human DYNLT1 (NM_006519.2) - SHH282225 from Creative biogene
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Human DYNLT1 siRNA - orb265277 from Biorbyt
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DYNLT1 shRNA Plasmid (Human) - CHH4775 from Cohesion Biosciences
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DYNLT1 miRNA 3'UTR clone - MiUTR3H-04204 from Creative biogene
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