Gene Symbol | HNF1A |
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Entrez Gene | 6927 |
Alt Symbol | HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1 |
Species | Human |
Gene Type | protein-coding |
Description | HNF1 homeobox A |
Other Description | HNF-1-alpha|albumin proximal factor|hepatic nuclear factor 1|hepatocyte nuclear factor 1-alpha|interferon production regulator factor|liver-specific transcription factor LF-B1|transcription factor 1, hepatic |
Swissprots | E2I9R4 E0YMK1 E0YMK0 E2I9R5 E0YMJ5 A5Z2R8 Q2M3H2 Q99861 F5H5U3 P20823 |
Accessions | AAC51137 AAD14878 ABR09270 ACL15377 ACL15378 ACL15379 ACL15380 ACL15381 ACL15382 ACL15383 ACL15384 ACL15385 ACL15386 ACL15387 ACL15388 ACL15389 ACL15390 ACL15391 ACL15392 ACL15393 EAW98226 EAW98227 EAW98228 P20823 AK298422 BAG60646 AW294801 BC104908 AAI04909 BC104910 AAI04911 BC143483 BE348240 BM854591 EU446660 ABZ92189 HM116541 ADM43481 HM116542 ADM43482 HM116543 ADM43483 HM116544 ADM43484 HM116545 ADM43485 HM116546 ADM43486 HM116547 ADM43487 HM116548 ADM43488 HM116549 HM116550 HM116551 HM116552 ADM43489 HM116557 ADM43494 HM116558 ADM43495 HM116559 ADM43496 HM116560 HM116561 ADM43497 HM116562 HM116563 ADM43498 HM449088 ADK56177 HM449089 ADK56178 M57732 AAA88077 X71346 CAB59201 X71347 XM_005253931 XP_005253988 XM_011538713 XP_011537015 NM_000545 NP_000536 NM_001306179 NP_001293108 |
Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. {ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:10966642}. |
Tissue Specificity | Liver. |
Top Pathways | Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells |
HNF1α Antibody - 12425 from Cell Signaling Technology
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HNF-1 (F-7) - sc-393925 from Santa Cruz Biotechnology
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HNF-1 (H-205) - sc-8986 from Santa Cruz Biotechnology
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HNF-1α (B-3) - sc-393668 from Santa Cruz Biotechnology
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HNF-1α (C-19) - sc-6547 from Santa Cruz Biotechnology
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HNF-1α (H-140) - sc-10791 from Santa Cruz Biotechnology
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HNF-1α (N-19) - sc-6548 from Santa Cruz Biotechnology
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HNF-1α (2) - sc-135939 from Santa Cruz Biotechnology
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Anti-HNF1 antibody - ab203092 from Abcam
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Anti-HNF1 antibody - ab118580 from Abcam
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Anti-HNF1 antibody - ab174653 from Abcam
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Anti-HNF1 antibody [GT4110] - ab184194 from Abcam
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Anti-HNF1A / HNF1 Antibody (aa192-205) - LS-C55568 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, AP) - LS-C283419 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (aa179-228) - LS-C107825 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, APC) - LS-C283421 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, Biotin) - LS-C283422 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, FITC) - LS-C283423 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (N-Terminus) - LS-C152705 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (aa617-631) IHC-plus⢠- LS-B5116 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, PE) - LS-C283425 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (Internal, Azide-free, HRP) - LS-C283424 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody - LS-C26585 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (aa177-205) - LS-C159856 from LifeSpan Bioscience
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Anti-HNF1A / HNF1 Antibody (aa50-100) - LS-C290696 from LifeSpan Bioscience
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