| Gene Symbol |
SLC28A1
|
| Entrez Gene |
9154
|
| Alt Symbol |
CNT1, HCNT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 28 (concentrative nucleoside transporter), member 1
|
| Other Description |
Na(+)/nucleoside cotransporter 1|concentrative nucleoside transporter 1|sodium-coupled nucleoside transporter 1|sodium/nucleoside cotransporter 1|solute carrier family 28 (sodium-coupled nucleoside transporter), member 1|solute carrier family 28 member 1
|
| Swissprots |
Q5U648 A0AV42 O00337 Q5U5S6 O00336 O00335 Q9UEZ9 A8K7I2
|
| Accessions |
AAF15353 EAX01962 EAX01963 EAX01964 O00337 AF309632 AAL09447 AK291997 BAF84686 AK296074 BAH12251 AK296075 BAH12252 AK296119 BAH12260 AK298369 BAH12769 AK309571 AK309578 AK311387 BC029788 AAH29788 BC039898 AAH39898 BC126204 AAI26205 BC126206 AAI26207 BC143908 BI765705 HQ258352 ADR83106 U62967 AAB53838 U62968 AAB53839 XM_011522203 XP_011520505 XM_011522204 XP_011520506 XM_011522205 XP_011520507 XM_011522206 XP_011520508 XM_011522207 XP_011520509 XM_011522208 XP_011520510 XM_011522209 XP_011520511 XM_011522210 XP_011520512 XM_011522211 XP_011520513 XM_011522212 XP_011520514 XM_011522213 XP_011520515 XM_011522214 XP_011520516 XM_011522215 XP_011520517 XM_011522216 XP_011520518 XM_011522217 XP_011520519 XM_011522218 XP_011520520 XR_931944 XR_931945 NM_001287761 NP_001274690 NM_001287762 NP_001274691 NM_004213 NP_004204 NM_201651 NP_964014
|
| Function |
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in kidney.
|