| Gene Symbol |
ssrp1
|
| Entrez Gene |
399344
|
| Alt Symbol |
-
|
| Species |
Xenopus
|
| Gene Type |
protein-coding
|
| Description |
structure specific recognition protein 1
|
| Other Description |
DNA unwinding factor 87 kDa subunit|DUF87|FACT complex subunit SSRP1|facilitates chromatin transcription complex subunit ssrp1|structure-specific recognition protein 1
|
| Swissprots |
Q640L1 Q9W602
|
| Accessions |
Q9W602 AB004793 BAA76333 BC082613 AAH82613 NM_001090695 NP_001084164
|
| Function |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA. {ECO:0000269|PubMed:10209116, ECO:0000269|PubMed:12646158}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus {ECO:0000250}. Chromosome.
|