MGST1
| Gene Symbol | MGST1 |
|---|---|
| Entrez Gene | 4257 |
| Alt Symbol | GST12, MGST, MGST-I |
| Species | Human |
| Gene Type | protein-coding |
| Description | microsomal glutathione S-transferase 1 |
| Other Description | glutathione S-transferase 12|microsomal GST-1|microsomal GST-I |
| Swissprots | A8K533 P10620 G5EA53 |
| Accessions | AAB17184 AAC50711 AAQ55111 EAW96362 EAW96363 EAW96364 EAW96365 EAW96366 EAW96367 EAW96368 EAW96369 P10620 AA314967 AK123482 AK291148 BAF83837 AK309707 AV655242 AW166965 BC005923 AAH05923 BC056863 BC062473 BE568125 BG569388 BG617746 BG778603 BT006982 AAP35628 CR407629 CAG28557 H49331 J03746 AAA35934 R86750 XM_006719079 XP_006719142 XM_006719080 XP_006719143 XM_011520673 XP_011518975 XM_011520674 XP_011518976 XM_011520675 XP_011518977 NM_001260511 NP_001247440 NM_001260512 NP_001247441 NM_001267598 NP_001254527 NM_020300 NP_064696 NM_145764 NP_665707 NM_145791 NP_665734 NM_145792 NP_665735 NR_048545 NR_048547 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. |
| Subcellular Location | Microsome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Highly expressed in liver. |
| Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |
MGST1 CRISPR/Cas9 KO Plasmid (h) - sc-416990 from Santa Cruz Biotechnology
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MGST1 HDR Plasmid (h) - sc-416990-HDR from Santa Cruz Biotechnology
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MGST1 Double Nickase Plasmid (h) - sc-416990-NIC from Santa Cruz Biotechnology
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MGST1 Double Nickase Plasmid (h2) - sc-416990-NIC-2 from Santa Cruz Biotechnology
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MGST1 CRISPR Activation Plasmid (h) - sc-416990-ACT from Santa Cruz Biotechnology
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MGST1 CRISPR Activation Plasmid (h2) - sc-416990-ACT-2 from Santa Cruz Biotechnology
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MGST1 Lentiviral Activation Particles (h) - sc-416990-LAC from Santa Cruz Biotechnology
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MGST1 Lentiviral Activation Particles (h2) - sc-416990-LAC-2 from Santa Cruz Biotechnology
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MGST1 siRNA (h) - sc-40740 from Santa Cruz Biotechnology
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MGST1 shRNA Plasmid (h) - sc-40740-SH from Santa Cruz Biotechnology
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MGST1 shRNA (h) Lentiviral Particles - sc-40740-V from Santa Cruz Biotechnology
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Microsomal Glutathione S-transferase 1 RNAi - H00004257-R02 from Novus Biologicals
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Microsomal Glutathione S-transferase 1 RNAi - H00004257-R01 from Novus Biologicals
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Microsomal Glutathione S-transferase 1 RNAi - H00004257-R03 from Novus Biologicals
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MISSION® esiRNA - EHU080961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13306 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13306 from Sigma-Aldrich
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MGST1 siRNA (Human) - CRH2895 from Cohesion Biosciences
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Microsomal Glutathione S-transferase 1 RNAi - H00004257-R04 from Novus Biologicals
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shRNA set against Human MGST1 (NM_020300.4) - SHH341719 from Creative biogene
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MGST1 shRNA Plasmid (Human) - CHH2895 from Cohesion Biosciences
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MGST1 miRNA 3'UTR clone - MiUTR3H-00905 from Creative biogene
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MGST1 miRNA 3'UTR clone - MiUTR3H-00906 from Creative biogene
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MGST1 miRNA 3'UTR clone - MiUTR3H-00907 from Creative biogene
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MGST1 miRNA 3'UTR clone - MiUTR3H-00908 from Creative biogene
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