Gene Symbol | Htr4 |
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Entrez Gene | 15562 |
Alt Symbol | 5-HT-4, 5-HT4, 5-HT<4L>, 5HTR4 |
Species | Mouse |
Gene Type | protein-coding |
Description | 5 hydroxytryptamine (serotonin) receptor 4 |
Other Description | 5-hydroxytryptamine receptor 4|serotonin receptor 4 |
Swissprots | P97288 Q9R2A4 O89004 Q3URB5 O89003 |
Accessions | EDL09741 EDL09742 EDL09743 EDL09744 P97288 AJ011369 CAA09598 AK141587 BAE24750 AK141625 BAE24773 BC132189 BC132191 BC145159 BC145161 BC148470 AAI48471 BC153066 AAI53067 JN418927 AET74078 JN418928 AET74079 JN418929 AET74080 JN418930 AET74081 Y09585 CAA70773 Y09587 CAA70775 Y09588 CAA70776 XM_006525675 XP_006525738 XM_006525676 XP_006525739 XM_006525678 XP_006525741 XM_006525680 XP_006525743 XM_006525681 XP_006525744 XM_006525682 XP_006525745 XM_006525683 XP_006525746 XM_011246847 XP_011245149 XM_011246848 XP_011245150 NM_008313 NP_032339 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. |
Top Pathways | Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-4 CRISPR/Cas9 KO Plasmid (m) - sc-420997 from Santa Cruz Biotechnology
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SR-4 HDR Plasmid (m) - sc-420997-HDR from Santa Cruz Biotechnology
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SR-4 Double Nickase Plasmid (m) - sc-420997-NIC from Santa Cruz Biotechnology
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SR-4 Double Nickase Plasmid (m2) - sc-420997-NIC-2 from Santa Cruz Biotechnology
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SR-4 CRISPR Activation Plasmid (m) - sc-420997-ACT from Santa Cruz Biotechnology
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SR-4 CRISPR Activation Plasmid (m2) - sc-420997-ACT-2 from Santa Cruz Biotechnology
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SR-4 Lentiviral Activation Particles (m) - sc-420997-LAC from Santa Cruz Biotechnology
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SR-4 Lentiviral Activation Particles (m2) - sc-420997-LAC-2 from Santa Cruz Biotechnology
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SR-4 siRNA (m) - sc-42240 from Santa Cruz Biotechnology
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SR-4 shRNA Plasmid (m) - sc-42240-SH from Santa Cruz Biotechnology
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SR-4 shRNA (m) Lentiviral Particles - sc-42240-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33553 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33553 from Sigma-Aldrich
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HTR4 siRNA (Mouse) - CRM1966 from Cohesion Biosciences
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HTR4 - MBS8217187 from MyBioSource
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shRNA set against Mouse HTR4 (NM_008313.4) - SHH315989 from Creative biogene
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shRNA set against Mouse Htr4(NM_008313.4) - SHH135967 from Creative biogene
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Mouse HTR4 siRNA - orb281442 from Biorbyt
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HTR4 shRNA Plasmid (Mouse) - CHM1966 from Cohesion Biosciences
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HTR4 miRNA 3'UTR clone - MiUTR1M-05850 from Creative biogene
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