| Gene Symbol |
KLHL13
|
| Entrez Gene |
90293
|
| Alt Symbol |
BKLHD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 13
|
| Other Description |
BTB and kelch domain containing 2|kelch-like 13|kelch-like protein 13
|
| Swissprots |
B3KV78 B3KWM7 Q6P2E3 D3DWH6 Q9UDN9 B7Z802 Q9P2N7 B7Z5P2 Q96QI7 B7Z3S9
|
| Accessions |
AAF03529 EAW89898 EAW89899 EAW89900 Q9P2N7 AB037730 BAA92547 AK001124 BAA91514 AK122724 BAG53690 AK125356 BAG54189 AK296324 BAH12315 AK297523 BAH12605 AK299257 BAH12978 AK302713 BAH13788 AK316509 BAH14880 AL591986 CAC41335 BC008729 AAH08729 BC064576 AAH64576 BP380009 DA214831 DA413195 DB074659 DC343916 DC354391 EU446550 ABZ92079 XM_011531409 XP_011529711 XM_011531410 XP_011529712 XM_011531411 XP_011529713 NM_001168299 NP_001161771 NM_001168300 NP_001161772 NM_001168301 NP_001161773 NM_001168302 NP_001161774 NM_001168303 NP_001161775 NM_033495 NP_277030
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: KLHL13 Overexpression Lysate (Adult Normal) [NBL1-12334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KLHL13.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6963_KLHL13%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12334-img0002.jpg)