| Gene Symbol |
DDB1
|
| Entrez Gene |
1642
|
| Alt Symbol |
DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
damage-specific DNA binding protein 1, 127kDa
|
| Other Description |
DDB p127 subunit|DNA damage-binding protein 1|DNA damage-binding protein a|HBV X-associated protein 1|UV-DDB 1|UV-damaged DNA-binding factor|UV-damaged DNA-binding protein 1|XAP-1|XPE-binding factor|xeroderma pigmentosum group E-complementing protein
|
| Swissprots |
O15176 Q58F96 B2R648 Q16531 Q13289 B4DG00 A6NG77
|
| Accessions |
AAX44048 EAW73933 EAW73934 EAW73935 EAW73936 EAW73937 Q16531 AA665872 AJ002955 CAA05770 AK294341 BAG57611 AK294493 BAH11787 AK299650 BAG61570 AK302924 BAH13845 AK303032 BAG64157 AK311476 AK312436 BAG35345 AL831958 BC011686 AAH11686 BC021044 BC032080 BC050530 AAH50530 BC051764 AAH51764 CD242268 DC334780 L40326 AAA62838 U18299 AAC50349 U32986 AAA88883 NM_001923 NP_001914
|
| Function |
Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate t
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Nucleotide excision repair, Viral carcinogenesis
|
