Gene Symbol | CDH15 |
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Entrez Gene | 1013 |
Alt Symbol | CDH14, CDH3, CDHM, MCAD, MRD3 |
Species | Human |
Gene Type | protein-coding |
Description | cadherin 15, type 1, M-cadherin (myotubule) |
Other Description | cadherin-14|cadherin-15|cadherin-3|muscle-cadherin |
Swissprots | P55291 |
Accessions | EAW66741 EAW66742 P55291 AK308596 AK308631 AW452260 BC008951 AAH08951 D83542 BAA12012 DQ893277 ABM84203 DQ896608 ABM87607 XM_011522806 XP_011521108 NM_004933 NP_004924 |
Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in the brain and cerebellum. {ECO:0000269|PubMed:19012874}. |
Top Pathways | Cell adhesion molecules (CAMs) |
M-cadherin CRISPR/Cas9 KO Plasmid (h) - sc-401232 from Santa Cruz Biotechnology
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M-cadherin HDR Plasmid (h) - sc-401232-HDR from Santa Cruz Biotechnology
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M-cadherin Double Nickase Plasmid (h) - sc-401232-NIC from Santa Cruz Biotechnology
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M-cadherin Double Nickase Plasmid (h2) - sc-401232-NIC-2 from Santa Cruz Biotechnology
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M-cadherin CRISPR Activation Plasmid (h) - sc-401232-ACT from Santa Cruz Biotechnology
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M-cadherin CRISPR Activation Plasmid (h2) - sc-401232-ACT-2 from Santa Cruz Biotechnology
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M-cadherin Lentiviral Activation Particles (h) - sc-401232-LAC from Santa Cruz Biotechnology
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M-cadherin Lentiviral Activation Particles (h2) - sc-401232-LAC-2 from Santa Cruz Biotechnology
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M-cadherin siRNA (h) - sc-37041 from Santa Cruz Biotechnology
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M-cadherin shRNA Plasmid (h) - sc-37041-SH from Santa Cruz Biotechnology
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M-cadherin shRNA (h) Lentiviral Particles - sc-37041-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5811 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02751 from Sigma-Aldrich
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CDH15 siRNA (Human) - CRH0726 from Cohesion Biosciences
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M-Cadherin/Cadherin-15 RNAi - H00001013-R01 from Novus Biologicals
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CDH15 - MBS8215501 from MyBioSource
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M-cadherin CRISPR/Cas9 KO Plasmid (h2) - sc-401232-KO-2 from Santa Cruz Biotechnology
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M-cadherin HDR Plasmid (h2) - sc-401232-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CDH15 (NM_004933.2) - SHH260173 from Creative biogene
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shRNA set against Human CDH15(NM_004933.2) - SHG163087 from Creative biogene
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Human CDH15 siRNA - orb261228 from Biorbyt
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CDH15 shRNA Plasmid (Human) - CHH0726 from Cohesion Biosciences
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CDH15 miRNA 3'UTR clone - MiUTR1H-01973 from Creative biogene
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