| Gene Symbol |
ALDH3B1
|
| Entrez Gene |
221
|
| Alt Symbol |
ALDH4, ALDH7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aldehyde dehydrogenase 3 family, member B1
|
| Other Description |
aldehyde dehydrogenase 3B1|aldehyde dehydrogenase 7|aldehyde dehydrogenase family 3 member B1
|
| Swissprots |
P43353 Q8N515 Q53XL5 Q96CK8 A3FMP9
|
| Accessions |
EAW74678 EAW74679 EAW74680 EAW74681 EAW74682 EAW74683 P43353 AB209651 BAD92888 AK092029 AK291505 BAF84194 BC002553 AAH02553 BC013584 AAH13584 BC014168 AAH14168 BC019911 BC033099 AAH33099 BM561843 BT009832 AAP88834 CD014083 CD014084 CK299957 DA624671 DA630186 DQ891452 ABM82378 DQ894631 ABM85557 EF411198 ABN58743 U10868 AAA83428 X75688 NM_000694 NP_000685 NM_001030010 NP_001025181 NM_001161473 NP_001154945 NM_001290058 NP_001276987 NM_001290059 NP_001276988
|
| Function |
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. {ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:23721920}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23721920}; Lipid-anchor {ECO:0000269|PubMed:23721920}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
|
| Tissue Specificity |
Highest expression in kidney and lung.
|
| Top Pathways |
Chemical carcinogenesis, Glycolysis / Gluconeogenesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tyrosine metabolism
|
