Gene Symbol | NDUFS8 |
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Entrez Gene | 4728 |
Alt Symbol | CI-23k, CI23KD, TYKY |
Species | Human |
Gene Type | protein-coding |
Description | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) |
Other Description | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial|NADH-ubiquinone oxidoreductase 23 kDa subunit|complex I 23kDa subunit|complex I-23kD |
Swissprots | O00217 B2RB86 Q0VDA8 |
Accessions | AAC34273 EAW74685 EAW74686 EAW74687 EAW74688 O00217 AK002110 AK223114 BAD96834 AK302449 BAG63745 AK314546 BAG37133 BC119753 AAI19754 BC119754 AAI19755 DB498707 U65579 AAB51776 XM_005274013 XP_005274070 XM_005274014 XP_005274071 XM_005274015 XP_005274072 XM_011545053 XP_011543355 NM_002496 NP_002487 |
Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000305}. |
Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
NDUFS8 CRISPR/Cas9 KO Plasmid (h) - sc-410905 from Santa Cruz Biotechnology
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NDUFS8 HDR Plasmid (h) - sc-410905-HDR from Santa Cruz Biotechnology
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NDUFS8 Double Nickase Plasmid (h) - sc-410905-NIC from Santa Cruz Biotechnology
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NDUFS8 Double Nickase Plasmid (h2) - sc-410905-NIC-2 from Santa Cruz Biotechnology
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NDUFS8 CRISPR Activation Plasmid (h) - sc-410905-ACT from Santa Cruz Biotechnology
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NDUFS8 CRISPR Activation Plasmid (h2) - sc-410905-ACT-2 from Santa Cruz Biotechnology
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NDUFS8 Lentiviral Activation Particles (h) - sc-410905-LAC from Santa Cruz Biotechnology
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NDUFS8 Lentiviral Activation Particles (h2) - sc-410905-LAC-2 from Santa Cruz Biotechnology
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NDUFS8 siRNA (h) - sc-96551 from Santa Cruz Biotechnology
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NDUFS8 shRNA Plasmid (h) - sc-96551-SH from Santa Cruz Biotechnology
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NDUFS8 shRNA (h) Lentiviral Particles - sc-96551-V from Santa Cruz Biotechnology
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NDUFS8 RNAi - H00004728-R01 from Novus Biologicals
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MISSION® esiRNA - EHU053841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15173 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15173 from Sigma-Aldrich
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NDUFS8 siRNA (Human) - CRH3140 from Cohesion Biosciences
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Human NDUFS8 siRNA - orb263642 from Biorbyt
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NDUFS8 shRNA Plasmid (Human) - CHH3140 from Cohesion Biosciences
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