| Gene Symbol |
ITGB1BP1
|
| Entrez Gene |
9270
|
| Alt Symbol |
ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin beta 1 binding protein 1
|
| Other Description |
ICAP-1|bodenin|integrin beta-1-binding protein 1|integrin cytoplasmic domain-associated protein 1|integrin cytoplasmic domain-associated protein 1-alpha|integrin cytoplasmic domain-associated protein 1-beta
|
| Swissprots |
O14714 Q53RS0 O14713 D6W4Y9
|
| Accessions |
AAY14857 EAX00991 EAX00992 EAX00993 EAX00994 EAX00995 EAX00996 EAX00997 EAX00998 EAX00999 EAX01000 EAX01001 O14713 AF012023 AAB88671 AF012024 AAB88672 AK092115 AK093179 AK289817 BAF82506 AK299017 BAG61097 BC012264 AAH12264 BG032225 BM823938 BQ425555 BX647099 CR457006 CAG33287 DA751320 DQ894485 ABM85411 EU176272 ABW03723 XM_005246183 XP_005246240 XM_005246184 XP_005246241 XM_005246185 XP_005246242 XM_005246186 XP_005246243 XM_005246187 XP_005246244 XM_005246188 XP_005246245 XM_005246189 XP_005246246 XM_006711903 XP_006711966 XM_011510416 XP_011508718 NM_004763 NP_004754 NM_022334 NP_071729
|
| Function |
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin- dependent manner. Involved in the regulation of beta-1 integrin- containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPa
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen.
|
| Tissue Specificity |
Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate. {ECO:0000269|PubMed:9281591, ECO:0000269|PubMed:9867804}.
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