| Gene Symbol | IRF3 |
|---|---|
| Entrez Gene | 3661 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon regulatory factor 3 |
| Other Description | - |
| Swissprots | Q5FBY1 B2RAZ3 Q5FBY4 Q7Z5G6 Q14653 A8K7L2 Q5FBY2 |
| Accessions | AAC68818 AAD05262 EAW52510 EAW52511 EAW52512 EAW52513 Q14653 AA568913 AB102884 BAD89413 AB102886 BAD89415 AB102887 BAD89416 AK057577 AK292027 BAF84716 AK314421 BAG37040 BC000660 AAH00660 BC009395 AAH09395 BC071721 AAH71721 BM477213 BP347627 BU859806 CB961512 DA938709 DA999381 DQ893455 ABM84381 DQ896306 ABM87305 HM357932 ADN86147 HM357933 ADN86148 HM357934 ADN86149 HM357935 ADN86150 HM357936 ADN86151 HM357937 ADN86152 Z56281 CAA91227 XM_006723197 XP_006723260 XM_006723198 XP_006723261 XM_006723199 XP_006723262 XM_006723200 XP_006723263 XM_006723201 XP_006723264 XM_006723202 XP_006723265 XR_935819 XR_935820 NM_001197122 NP_001184051 NM_001197123 NP_001184052 NM_001197124 NP_001184053 NM_001197125 NP_001184054 NM_001197126 NP_001184055 NM_001197127 NP_001184056 NM_001197128 NP_001184057 NM_001571 NP_001562 NR_045568 |
| Function | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10805757}. Nucleus {ECO:0000269|PubMed:10805757}. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. |
| Tissue Specificity | Expressed constitutively in a variety of tissues. |
| Top Pathways | Hepatitis C, Pertussis, Toll-like receptor signaling pathway, Measles, Influenza A |