Gene Symbol | PNOC |
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Entrez Gene | 5368 |
Alt Symbol | PPNOC |
Species | Human |
Gene Type | protein-coding |
Description | prepronociceptin |
Other Description | nociceptin|nocistatin|propronociceptin |
Swissprots | Q6FH16 B7Z749 Q13519 |
Accessions | AAG38294 CAA66039 EAW63526 EAW63527 Q13519 AK289633 BAF82322 AK301456 BAH13485 AY335948 AAP94601 BC034758 AAH34758 BF976583 BT019334 AAV38141 CA412176 CR541940 CAG46738 CR541965 CAG46763 DA403369 DQ891296 ABM82222 DQ894480 ABM85406 U48263 AAC50651 X97370 CAA66040 XM_005273532 XP_005273589 XM_011544559 XP_011542861 NM_001284244 NP_001271173 NM_006228 NP_006219 |
Function | Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. {ECO:0000269|PubMed:12950177}. |
Nociceptin CRISPR/Cas9 KO Plasmid (h) - sc-405013 from Santa Cruz Biotechnology
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Nociceptin HDR Plasmid (h) - sc-405013-HDR from Santa Cruz Biotechnology
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Nociceptin Double Nickase Plasmid (h) - sc-405013-NIC from Santa Cruz Biotechnology
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Nociceptin Double Nickase Plasmid (h2) - sc-405013-NIC-2 from Santa Cruz Biotechnology
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Nociceptin CRISPR Activation Plasmid (h) - sc-405013-ACT from Santa Cruz Biotechnology
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Nociceptin CRISPR Activation Plasmid (h2) - sc-405013-ACT-2 from Santa Cruz Biotechnology
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Nociceptin Lentiviral Activation Particles (h) - sc-405013-LAC from Santa Cruz Biotechnology
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Nociceptin Lentiviral Activation Particles (h2) - sc-405013-LAC-2 from Santa Cruz Biotechnology
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Nociceptin siRNA (h) - sc-106306 from Santa Cruz Biotechnology
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Nociceptin shRNA Plasmid (h) - sc-106306-SH from Santa Cruz Biotechnology
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Nociceptin shRNA (h) Lentiviral Particles - sc-106306-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17060 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17060 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03546 from Sigma-Aldrich
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PNOC siRNA (Human) - CRH3605 from Cohesion Biosciences
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shRNA set against Human PNOC (NM_006228.3) - SHH378748 from Creative biogene
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shRNA set against Human PNOC(NM_006228.3) - SHR125160 from Creative biogene
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Human PNOC siRNA - orb264107 from Biorbyt
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PNOC shRNA Plasmid (Human) - CHH3605 from Cohesion Biosciences
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PNOC miRNA 3'UTR clone - MiUTR1H-08050 from Creative biogene
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