| Gene Symbol | GNAI2 |
|---|---|
| Entrez Gene | 2771 |
| Alt Symbol | GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| Other Description | GTP-binding regulatory protein Gi alpha-2 chain|adenylate cyclase-inhibiting G alpha protein|guanine nucleotide-binding protein G(i) subunit alpha-2|guanine nucleotide-binding protein G(i), alpha-2 subunit |
| Swissprots | Q8IZ71 B4E2X5 P04899 Q6B6N3 B4DYA0 B3KTZ0 |
| Accessions | AAA35894 AAD12229 AAD12230 CAA30703 EAW65051 EAW65052 EAW65053 EAW65054 EAW65055 EAW65056 P04899 AF493906 AAM12620 AK055574 BAG51536 AK096299 BAG53252 AK096595 BAG53334 AK126708 BAG54363 AK131062 AK302330 BAG63662 AK304473 BAG65287 AY677118 AAT78421 BC012138 AAH12138 BC014627 AAH14627 BC016995 AAH16995 CR456783 CAG33064 DA528337 DB044421 DQ892783 ABM83709 DQ895908 ABM86834 HY037331 J03004 AAA52556 X04828 CAA28512 NM_001166425 NP_001159897 NM_001282617 NP_001269546 NM_001282618 NP_001269547 NM_001282619 NP_001269548 NM_001282620 NP_001269549 NM_002070 NP_002061 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. |
| Top Pathways | Circadian entrainment, Oxytocin signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes, Glutamatergic synapse |
G α i-2 CRISPR/Cas9 KO Plasmid (h) - sc-400568 from Santa Cruz Biotechnology
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G α i-2 HDR Plasmid (h) - sc-400568-HDR from Santa Cruz Biotechnology
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G α i-2 Double Nickase Plasmid (h) - sc-400568-NIC from Santa Cruz Biotechnology
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G α i-2 Double Nickase Plasmid (h2) - sc-400568-NIC-2 from Santa Cruz Biotechnology
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G α i-2 CRISPR Activation Plasmid (h) - sc-400568-ACT from Santa Cruz Biotechnology
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G α i-2 CRISPR Activation Plasmid (h2) - sc-400568-ACT-2 from Santa Cruz Biotechnology
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G α i-2 Lentiviral Activation Particles (h) - sc-400568-LAC from Santa Cruz Biotechnology
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G α i-2 Lentiviral Activation Particles (h2) - sc-400568-LAC-2 from Santa Cruz Biotechnology
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G α i-2 siRNA (h) - sc-41752 from Santa Cruz Biotechnology
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G α i-2 shRNA Plasmid (h) - sc-41752-SH from Santa Cruz Biotechnology
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G α i-2 shRNA (h) Lentiviral Particles - sc-41752-V from Santa Cruz Biotechnology
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G protein alpha Inhibitor 2 RNAi - H00002771-R01 from Novus Biologicals
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MISSION® esiRNA - EHU068811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9405 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9405 from Sigma-Aldrich
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GNAI2 siRNA (Human) - CRH1842 from Cohesion Biosciences
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GNAI2 - MBS8232932 from MyBioSource
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shRNA set against Human GNAI2 (NM_002070.2) - SHH304626 from Creative biogene
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shRNA set against Human GNAI2(NM_002070.2) - SHH091217 from Creative biogene
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Human GNAI2 siRNA - orb262344 from Biorbyt
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GNAI2 shRNA Plasmid (Human) - CHH1842 from Cohesion Biosciences
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GNAI2 miRNA 3'UTR clone - MiUTR1H-04101 from Creative biogene
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