| Gene Symbol |
Acot7
|
| Entrez Gene |
26759
|
| Alt Symbol |
Bach
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA thioesterase 7
|
| Other Description |
ACH1|ACT|CTE-II|CTE-IIa|CTE-IIb|LACH1|MTE-II|brain acyl-CoA hydrolase|cytosolic acyl coenzyme A thioester hydrolase|long chain acyl-CoA thioester hydrolase
|
| Swissprots |
O08652 O09041 Q64559
|
| Accessions |
EDL81226 EDL81227 Q64559 BC087716 AAH87716 CK469690 D88891 BAA19627 DY317682 FQ212652 FQ231740 U49694 AAC53202 Y09332 CAA70512 XM_006239447 XP_006239509 XM_006239448 XP_006239510 NM_001146061 NP_001139533 NM_013214 NP_037346
|
| Function |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Isoform 1 is expressed constitutively in brain and testis. Isoform 2 is induced in liver by treatment with the peroxisome proliferator.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids
|