| Gene Symbol |
MARCH9
|
| Entrez Gene |
92979
|
| Alt Symbol |
MARCH-IX, RNF179
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 9
|
| Other Description |
E3 ubiquitin-protein ligase MARCH9|RING finger protein 179|membrane-associated RING finger protein 9|membrane-associated RING-CH protein IX
|
| Swissprots |
Q86YJ5 B2R9U9 Q86VN5 Q96GG2
|
| Accessions |
EAW97063 EAW97064 EAW97065 Q86YJ5 AK093897 BAC04247 AK313925 BAG36646 BC009489 AAH09489 BC036455 AAH36455 BC050397 AAH50397 XM_011539007 XP_011537309 NM_138396 NP_612405
|
| Function |
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17174307}.
|
| Subcellular Location |
Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:14722266}.
|