TLR4
| Gene Symbol | TLR4 |
|---|---|
| Entrez Gene | 7099 |
| Alt Symbol | ARMD10, CD284, TLR-4, TOLL |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-like receptor 4 |
| Other Description | hToll|homolog of Drosophila toll |
| Swissprots | A9XLQ1 Q9UM57 Q9UK78 D1CS52 O00206 B4E194 Q5VZI8 D1CS53 A9XLP9 A9XLQ0 A8K1Y8 Q5VZI9 |
| Accessions | AAF05316 AAF07823 AAF89753 AAY82267 AAY82268 AAY82269 AAY82270 ABU41662 ABU41663 ABU41664 ACX46980 ACX46981 ACX46982 ACX46983 ACX46984 ACZ69536 ACZ69537 ACZ69538 ACZ69539 ACZ69540 ACZ69541 ACZ69542 ACZ69543 AFX71929 AFX71930 AFX71931 AFX71932 AFX71933 AFX71934 AFX71935 AFX71936 AFX71937 AFX71938 AFX71939 AFX71940 AFX71941 AFX71942 AFX71943 AFX71944 AFX71945 AFX71946 AFX71947 AFX71948 AFX71949 AFX71950 AFX71951 AFX71952 AFX71953 AFX71954 AFX71955 AFX71956 AFX71957 AFX71958 AFX71959 AFX71960 AFX71961 AFX71962 AFX71963 AFX71964 AFX71965 AFX71966 AFX71967 AFX71968 AFX71969 AFX71970 AFX71971 AFX71972 AFX71973 AFX71974 AFX71975 AFX71976 AFX71977 AFX71978 AFX71979 AFX71980 AFX71981 AFX71982 AFX71983 AFX71984 AFX71985 AFX71986 AFX71987 AFX71988 AFX71989 AFX71990 AFX71991 AFX71992 AFX71993 AFX71994 AFX71995 AFX71996 AFX71997 AFX71998 AFX71999 AFX72000 AFX72001 AFX72002 AFX72003 AFX72004 AFX72005 AFX72006 AFX72007 AFX72008 AFX72009 AFX72010 AFX72011 AFX72012 AFX72013 AFX72014 AFX72015 AFX72016 AFX72017 AFX72018 AFX72019 AFX72020 AFX72021 AFX72022 AFX72023 AFX72024 AFX72025 AFX72026 AFX72027 AFX72028 AFX72029 AFX72030 AFX72031 AFX72032 AFX72033 AFX72034 AFX72035 AFX72036 AFX72037 AFX72038 AFX72039 AFX72040 AFX72041 AFX72042 AFX72043 AFX72044 AFX72045 AFX72046 AFX72047 AFX72048 AFX72049 AFX72050 AFX72051 AFX72052 AFX72053 AFX72054 AFX72055 AFX72056 AFX72057 AFX72058 AFX72059 AFX72060 AFX72061 AFX72062 AFX72063 AFX72064 AFX72065 AFX72066 AFX72067 AFX72068 AFX72069 AFX72070 AFX72071 AFX72072 AFX72073 AFX72074 AFX72075 AFX72076 AFX72077 AFX72078 AFX72079 AFX72080 AFX72081 AFX72082 AFX72083 AFX72084 AFX72085 AFX72086 AFX72087 AFX72088 AFX72089 AFX72090 AFX72091 AFX72092 AFX72093 AFX72094 AFX72095 AFX72096 AFX72097 AFX72098 AFX72099 AFX72100 AFX72101 AFX72102 AFX72103 AFX72104 AFX72105 AFX72106 AFX72107 AFX72108 AFX72109 AFX72110 AFX72111 AFX72112 AFX72113 AFX72114 AFX72115 AFX72116 AFX72117 AFX72118 AFX72119 AFX72120 AFX72121 AFX72122 AFX72123 AFX72124 AFX72125 AFX72126 AFX72127 AFX72128 AFX72129 AFX72130 AFX72131 AFX72132 AFX72133 AFX72134 AFX72135 AFX72136 AFX72137 AFX72138 AFX72139 AFX72140 AFX72141 AFX72142 AFX72143 AFX72144 AFX72145 AFX72146 AFX72147 AFX72148 AFX72149 AFX72150 AFX72151 AFX72152 AFX72153 AFX72154 AFX72155 AFX72156 AFX72157 AFX72158 AFX72159 AFX72160 AFX72161 AFX72162 AFX72163 AFX72164 AFX72165 AFX72166 AFX72167 AFX72168 AFX72169 AFX72170 AFX72171 AFX72172 AFX72173 AFX72174 AFX72175 AFX72176 AFX72177 AFX72178 AFX72179 AFX72180 AFX72181 AFX72182 AFX72183 AFX72184 AFX72185 AFX72186 AFX72187 AFX72188 AFX72189 AFX72190 AFX72191 AFX72192 AFX72193 AFX72194 AFX72195 AFX72196 AFX72197 AFX72198 AFX72199 AFX72200 AFX72201 AFX72202 AFX72203 AFX72204 AFX72205 AFX72206 AFX72207 AFX72208 AFX72209 AFX72210 AFX72211 AFX72212 AFX72213 AFX72214 AFX72215 AFX72216 AFX72217 AFX72218 AFX72219 AFX72220 AFX72221 AFX72222 AFX72223 AFX72224 AFX72225 AFX72226 AFX72227 AFX72228 AFX72229 AFX72230 AFX72231 AFX72232 AFX72233 AFX72234 AFX72235 AFX72236 AFX72237 AFX72238 AFX72239 AFX72240 AFX72241 AFX72242 AFX72243 AFX72244 AFX72245 AFX72246 AFX72247 AFX72248 AFX72249 AFX72250 AFX72251 AFX72252 AFX72253 AFX72254 AFX72255 AFX72256 AFX72257 AFX72258 AFX72259 AFX72260 AFX72261 AFX72262 AFX72263 AFX72264 AFX72265 AFX72266 AFX72267 AFX72268 AFX72269 AFX72270 AFX72271 AFX72272 AFX72273 AFX72274 AFX72275 AFX72276 AFX72277 AFX72278 AFX72279 AFX72280 AFX72281 AFX72282 AFX72283 AFX72284 AFX72285 AFX72286 AFX72287 AFX72288 AFX72289 AFX72290 AFX72291 AFX72292 AFX72293 AFX72294 AFX72295 AFX72296 AFX72297 AFX72298 AFX72299 AFX72300 AFX72301 AFX72302 AFX72303 AFX72304 AFX72305 AFX72306 AFX72307 AFX72308 AFX72309 AFX72310 AFX72311 AFX72312 AFX72313 AFX72314 AFX72315 AFX72316 AFX72317 CAS02255 CAT16978 EAW87448 EAW87449 EAW87451 O00206 AA598398 AB445638 BAG55035 AK226155 AK290053 BAF82742 AK293068 BAF85757 AK303730 BAG64706 AL710219 BC025294 BC117422 AAI17423 BC143841 BG622357 DA126770 DA187988 DA218006 U69193 U88880 AAC34135 U93091 AAC80227 NM_003266 NP_003257 NM_138554 NP_612564 NM_138557 NP_612567 NM_138556 |
| Function | Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species- specific. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. {ECO:0000269|PubMed:20037584}. |
| Tissue Specificity | Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. |
| Top Pathways | Pertussis, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD), Legionellosis, Proteoglycans in cancer |
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