| Gene Symbol |
KIF13A
|
| Entrez Gene |
63971
|
| Alt Symbol |
RBKIN, bA500C11.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 13A
|
| Other Description |
homolog of mouse KIF13A mannose-6-phosphate receptor transporter|kinesin-like protein KIF13A|kinesin-like protein RBKIN
|
| Swissprots |
Q9H194 A0JP22 Q5THQ3 F2Z382 A0JP21 Q5THQ2 Q9H1H8 Q9H193 Q9H1H9
|
| Accessions |
EAW55387 EAW55388 EAW55389 EAW55390 EAW55391 Q9H1H9 AA037612 AI080622 AJ291578 CAC20442 AJ291579 CAC20443 AK025303 BAB15107 AK225214 AW296537 AY014403 AAG38890 AY014404 AAG38891 BC001730 BC023613 BC062673 BC127115 AAI27116 BC127116 AAI27117 BG481524 BQ184768 CA308223 XM_005249289 XP_005249346 XM_005249290 XP_005249347 XM_005249291 XP_005249348 XM_005249292 XP_005249349 XM_005249293 XP_005249350 XM_006715166 XP_006715229 XM_011514805 XP_011513107 XM_011514806 XP_011513108 NM_001105566 NP_001099036 NM_001105567 NP_001099037 NM_001105568 NP_001099038 NM_001243423 NP_001230352 NM_022113 NP_071396
|
| Function |
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane {ECO:0000250}. Note=Recruited to the midbody during cytokinesis.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart, brain and skeletal muscle. {ECO:0000269|PubMed:11374900, ECO:0000269|PubMed:11861365}.
|
