| Gene Symbol | IL16 |
|---|---|
| Entrez Gene | 3603 |
| Alt Symbol | LCF, NIL16, PRIL16, prIL-16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 16 |
| Other Description | lymphocyte chemoattractant factor|neuronal interleukin 16|pro-interleukin-16|prointerleukin 16 |
| Swissprots | H3BVH5 B9EGR6 A8MU65 Q6ZMQ7 A6NM20 Q6VVE6 Q9UP18 Q14005 B5TY35 Q16435 |
| Accessions | AAD15990 AAR89904 EAW99098 EAW99099 EAW99100 EAW99101 Q14005 AF053412 AAC12732 AK124565 BAC85888 AK124725 AK126222 BAC86494 AK128740 BAG54724 AK131530 BAD18668 AK222512 BAD96232 AK303659 BAH14009 AK308440 AL109669 AL109774 AL833554 AY324389 AAQ86961 BC040272 AAH40272 BC050362 AAH50362 BC064911 BC136660 AAI36661 CR749286 CAH18141 DB141707 FJ032370 ACI00236 M90391 AAD04636 S81601 AAB36371 U82972 AAB58261 XM_005254342 XP_005254399 XM_005254346 XP_005254403 XM_011521518 XP_011519820 XM_011521519 XP_011519821 XM_011521520 XP_011519822 XR_931805 NM_001172128 NP_001165599 NM_004513 NP_004504 NM_172217 NP_757366 |
| Function | Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Subcellular Location | Isoform 3: Cytoplasm. Nucleus. |
| Tissue Specificity | Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation. |