KCNJ2

Gene Symbol	KCNJ2
Entrez Gene	3759
Alt Symbol	ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
Species	Human
Gene Type	protein-coding
Description	potassium channel, inwardly rectifying subfamily J, member 2
Other Description	IRK-1|cardiac inward rectifier potassium channel|hIRK1|inward rectifier K+ channel KIR2.1|inward rectifier potassium channel 2|potassium inwardly-rectifying channel, subfamily J, member 2
Swissprots	P63252 P48049 O15110
Accessions	AAF73242 CAJ33689 EAW89092 P63252 AF011904 AAC39555 AF021139 AAB88797 AF153820 AAF73241 AK314081 BAG36779 BC152811 AAI52812 U12507 AAC50072 U16861 AAA91781 U22413 AAA64282 U24055 AAB50277 XM_011524779 XP_011523081 NM_000891 NP_000882
Function	Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
Subcellular Location	Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}.
Tissue Specificity	Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Top Pathways	Gastric acid secretion, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kir2.1 peptide - ab45531 from Abcam Category Peptide

Human Kir2.1 protein fragment - ab114391 from Abcam Category Protein Source Wheat germ Species Human

KCNJ2 / Kir2.1 Antibody Blocking Peptide - LS-E8551 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kir2.1 Protein - H00003759-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KCNJ2-Antibody-C-term-Blocking-Peptide - BP6926c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCNJ2 - H00003759-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KCNJ2 - H00003759-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human KCNJ2 - KCNJ2-27881TH from Creative Biomart Category Protein Source Wheat germ Species Human

KIR2.1 (C122) Peptide - BS9150P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Kir2.1 Blocking Peptide - abx161657 from Abbexa Category Peptide Species Human, Mouse, Rat

Kir2.1 Recombinant Protein Antigen - NBP1-87709PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNJ2 Peptide, Human - M34GP07968H from Creative Peptides Category Peptide Source Synthetic. Species Human

Kir2.1 Blocking Peptide - CBP4446 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PDZ domain scaffold protein anti-Human Kir2, Kir3, Kir4, Kir5 - SPD-L165 from Creative Biolabs Category Protein Source E. coli Species Human

Kir2.1 Blocking Peptide - orb392791 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Inward rectifier potassium channel 2 (KCNJ2), Recombinant Protein - MBS965539 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Inward rectifier potassium channel 2 (KCNJ2), Recombinant Protein - MBS7017693 from MyBioSource Category Protein Prices $1,230.00, $2,215.00, $3,425.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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