ACIN1

Gene Symbol ACIN1
Entrez Gene 22985
Alt Symbol ACINUS, ACN, fSAP152
Species Human
Gene Type protein-coding
Description apoptotic chromatin condensation inducer 1
Other Description apoptotic chromatin condensation inducer in the nucleus|functional spliceosome-associated protein 152
Swissprots Q9UKV3 Q9UG91 Q9UKV2 O75158 D3DS45 B2RTT4 Q9UKV1
Accessions EAW66186 EAW66187 EAW66188 Q9UKV3 AB014570 BAA31645 AF124726 AAD56724 AF124727 AAD56725 AF124728 AAD56726 AK299034 BAG61109 AL050382 CAB43681 AL833228 CAH10608 BC032770 BC140805 AAI40806 BX247975 CAD62309 CX786860 XM_005267415 XP_005267472 XM_005267416 XP_005267473 XM_005267418 XP_005267475 XM_006720081 XP_006720144 XM_011536569 XP_011534871 XM_011536570 XP_011534872 XR_429297 NM_001164814 NP_001158286 NM_001164815 NP_001158287 NM_001164816 NP_001158288 NM_001164817 NP_001158289 NM_014977 NP_055792
Function Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different f
Subcellular Location Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Tissue Specificity Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway

Apoptotic chromatin condensation inducer in the nucleus (ACIN1), Human, ELISA Kit - E01A1191 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Neurofibromin 2 (NF2), Human, ELISA Kit - SEB946Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 0.128ng/mL
Range 0.312-20ng/mL

Apoptotic chromatin condensation inducer in the nucleus (ACIN1), ELISA Kit - MBS7227632 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Neurofibromin 2 (NF2) - SEB946Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human ACIN1 ELISA Kit - E003433 from Biobool

Category ELISA Kit

anti-Acinus antibody - ARG54367 from Arigo Biolaboratories

Category ELISA Kit

anti-Acinus antibody - ARG54368 from Arigo Biolaboratories

Category ELISA Kit

anti-Acinus antibody - ARG54366 from Arigo Biolaboratories

Category ELISA Kit

anti-Acinus antibody - ARG54375 from Arigo Biolaboratories

Category ELISA Kit
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