Gene Symbol | PMF1 |
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Entrez Gene | 11243 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | polyamine-modulated factor 1 |
Other Description | Est1p-like protein B (EST1B) |
Swissprots | Q6ZVE6 Q5TCJ9 Q6P1K2 Q5TCK1 Q6PHR4 Q5TCK0 Q5TCJ8 Q86VJ6 A8K0C5 Q5TCK3 Q69YZ9 Q9UBQ3 Q8N4T6 |
Accessions | AAD50080 EAW52987 EAW52988 EAW52989 EAW52990 Q6P1K2 AF141310 AAD50081 AK022523 AK124646 BAC85916 AK289490 BAF82179 AK290260 BAF82949 AK307287 AK310694 AL080101 CAH10730 BC050735 AAH50735 BC056417 AAH56417 BC065031 AAH65031 DC310420 DT220098 EU832507 ACE87679 EU832588 ACE86990 NM_001199653 NP_001186582 NM_001199654 NP_001186583 NM_007221 NP_009152 |
Function | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000269|PubMed:10419538, ECO:0000269|PubMed:11256947, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore. |
Tissue Specificity | Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver. {ECO:0000269|PubMed:10419538}. |
PMF-1 CRISPR/Cas9 KO Plasmid (h) - sc-416611 from Santa Cruz Biotechnology
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PMF-1 HDR Plasmid (h) - sc-416611-HDR from Santa Cruz Biotechnology
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PMF-1 Double Nickase Plasmid (h) - sc-416611-NIC from Santa Cruz Biotechnology
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PMF-1 Double Nickase Plasmid (h2) - sc-416611-NIC-2 from Santa Cruz Biotechnology
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PMF-1 CRISPR Activation Plasmid (h) - sc-416611-ACT from Santa Cruz Biotechnology
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PMF-1 CRISPR Activation Plasmid (h2) - sc-416611-ACT-2 from Santa Cruz Biotechnology
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PMF-1 Lentiviral Activation Particles (h) - sc-416611-LAC from Santa Cruz Biotechnology
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PMF-1 Lentiviral Activation Particles (h2) - sc-416611-LAC-2 from Santa Cruz Biotechnology
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PMF-1 siRNA (h) - sc-78780 from Santa Cruz Biotechnology
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PMF-1 shRNA Plasmid (h) - sc-78780-SH from Santa Cruz Biotechnology
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PMF-1 shRNA (h) Lentiviral Particles - sc-78780-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU097171 from Sigma-Aldrich
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MISSION® esiRNA - EHU097911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17026 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17026 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03520 from Sigma-Aldrich
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PMF1 siRNA (Human) - CRH7705 from Cohesion Biosciences
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shRNA set against Human PMF1 (NM_007221.3) - SHH378372 from Creative biogene
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Human PMF1 siRNA - orb268207 from Biorbyt
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PMF1 shRNA Plasmid (Human) - CHH7705 from Cohesion Biosciences
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PMF1 miRNA 3'UTR clone - MiUTR3H-10454 from Creative biogene
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