| Gene Symbol |
KCNJ18
|
| Entrez Gene |
100134444
|
| Alt Symbol |
KIR2.6, TTPP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 18
|
| Other Description |
inward rectifier K(+) channel Kir2.6|inward rectifier potassium channel 18|thyrotoxic periodic paralysis susceptibility ion channel
|
| Swissprots |
B7U540
|
| Accessions |
B7U540 FJ434338 ACJ64506 XM_005276919 XP_005276976 NM_001194958 NP_001181887
|
| Function |
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:20074522}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Specifically expressed in skeletal muscle. {ECO:0000269|PubMed:20074522}.
|