| Gene Symbol |
supt16h
|
| Entrez Gene |
399345
|
| Alt Symbol |
-
|
| Species |
Xenopus
|
| Gene Type |
protein-coding
|
| Description |
suppressor of Ty 16 homolog
|
| Other Description |
DNA unwinding factor 140 kDa subunit|DUF140|FACT complex subunit SPT16|facilitates chromatin transcription complex subunit spt16
|
| Swissprots |
Q6GQJ6 Q9W603
|
| Accessions |
Q9W603 AB004794 BAA76334 BC169956 AAI69956 NM_001090697 NP_001084166
|
| Function |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome.
|