Gene Symbol | MUC5B |
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Entrez Gene | 727897 |
Alt Symbol | MG1, MUC-5B, MUC5, MUC9 |
Species | Human |
Gene Type | protein-coding |
Description | mucin 5B, oligomeric mucus/gel-forming |
Other Description | cervical mucin MUC5B|high molecular weight salivary mucin MG1|mucin 5, subtype B, tracheobronchial|mucin-5B|sublingual gland mucin |
Swissprots | O14985 Q9HC84 O00447 Q9UE28 O95291 Q14881 Q99552 Q7M4S5 O15494 O95451 O00573 |
Accessions | AAG33673 CAA06167 CAA70926 CAA96577 Q9HC84 AA577624 AF086604 AAC67545 AF253321 AAF64523 AK303892 BAG64826 AK310939 BM740816 BM796192 BM817984 CA450235 DC418119 S80993 AAB35930 U63836 AAB61398 U78550 AAC51342 U78551 AAC51343 U95031 AAB65151 X74370 CAA52408 X74954 CAA52909 X74955 CAA52910 X74956 CAA52911 NM_002458 NP_002449 |
Function | Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas. {ECO:0000269|PubMed:11713095, ECO:0000269|PubMed:8554565, ECO:0000269|PubMed:9147051, ECO:0000269|PubMed:9164870}. |
Top Pathways | Salivary secretion |
Mucin 5B CRISPR/Cas9 KO Plasmid (h) - sc-401077 from Santa Cruz Biotechnology
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Mucin 5B HDR Plasmid (h) - sc-401077-HDR from Santa Cruz Biotechnology
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Mucin 5B Double Nickase Plasmid (h) - sc-401077-NIC from Santa Cruz Biotechnology
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Mucin 5B Double Nickase Plasmid (h2) - sc-401077-NIC-2 from Santa Cruz Biotechnology
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Mucin 5B CRISPR Activation Plasmid (h) - sc-401077-ACT from Santa Cruz Biotechnology
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Mucin 5B CRISPR Activation Plasmid (h2) - sc-401077-ACT-2 from Santa Cruz Biotechnology
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Mucin 5B Lentiviral Activation Particles (h) - sc-401077-LAC from Santa Cruz Biotechnology
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Mucin 5B Lentiviral Activation Particles (h2) - sc-401077-LAC-2 from Santa Cruz Biotechnology
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Mucin 5B siRNA (h) - sc-106263 from Santa Cruz Biotechnology
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Mucin 5B shRNA Plasmid (h) - sc-106263-SH from Santa Cruz Biotechnology
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Mucin 5B shRNA (h) Lentiviral Particles - sc-106263-V from Santa Cruz Biotechnology
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Mucin 5B RNAi - H00727897-R01 from Novus Biologicals
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Mucin 5B RNAi - H00727897-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14760 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14760 from Sigma-Aldrich
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MUC5B siRNA (Human) - CRJ8627 from Cohesion Biosciences
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Mucin 5B RNAi - H00727897-R03 from Novus Biologicals
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Mucin 5B CRISPR/Cas9 KO Plasmid (h2) - sc-401077-KO-2 from Santa Cruz Biotechnology
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Mucin 5B HDR Plasmid (h2) - sc-401077-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MUC5B (NM_002458.2) - SHH346968 from Creative biogene
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Human MUC5B siRNA - orb279128 from Biorbyt
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MUC5B shRNA Plasmid (Human) - CHJ8627 from Cohesion Biosciences
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