CFL1

Gene Symbol	CFL1
Entrez Gene	1072
Alt Symbol	CFL, HEL-S-15
Species	Human
Gene Type	protein-coding
Description	cofilin 1 (non-muscle)
Other Description	18 kDa phosphoprotein|cofilin, non-muscle isoform|cofilin-1|epididymis secretory protein Li 15|p18
Swissprots	P23528 Q9UCA2 Q53Y87 B3KUQ1
Accessions	EAW74448 EAW74449 EAW74450 EAW74451 EAW74452 P23528 AK097690 BAG53513 AK303614 BAG64624 BC011005 AAH11005 BC012265 AAH12265 BC012318 AAH12318 BC018256 AAH18256 BC024975 BT006846 AAP35492 CB850882 D00682 BAA00589 D28345 BAA05711 DQ891769 ABM82695 EU176624 ABW03425 EU794603 ACJ13657 HM370399 U21909 AAA64501 X95404 CAA64685 NM_005507 NP_005498
Function	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. {ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.
Subcellular Location	Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue Specificity	Widely distributed in various tissues.
Top Pathways	Axon guidance, Fc gamma R-mediated phagocytosis, Pertussis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CFL1-cDNA-Clone - DC03055 from Abgent, a WuXi AppTec company Prices $224.10 Sizes 10 µg Species Human Accession BC011005

CFL1 - MBS1278744 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011005

CFL1 - MBS1277175 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC018256

Human CFL1 cDNA clone(NM_005507.2) - CDFH003524 from Creative Biomart Species Human Accession NM_005507.2

Human CFL1 ORF Clone(NM_005507.2) - CDCL158646 from Creative Biomart Species Human Accession NM_005507.2

Human CFL1 ORF Clone(NM_005507.2) - CDCR290652 from Creative Biomart Species Human Accession NM_005507.2

Human CFL1 ORF Clone(NM_005507.2) - CDCR290653 from Creative Biomart Species Human Accession NM_005507.2

Human CFL1 ORF Clone(NM_005507.2) - CDCR290654 from Creative Biomart Species Human Accession NM_005507.2

Human CFL1 / cofilin Gene ORF cDNA clone in cloning vector - HG14544-G from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14544-CM from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14544-ACG from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-His tag - HG14544-CH from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid - HG14544-UT from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-HA tag - HG14544-CY from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14544-ACR from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14544-NF from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, N-His tag - HG14544-NH from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14544-ANG from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14544-CF from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, N-HA tag - HG14544-NY from Sino Biological Species Human

Human CFL1 / cofilin Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14544-NM from Sino Biological Species Human

Human CFL1 ORF Clone(NM_005507.2) - CDCR290652 from Creative biogene Species Human

Human CFL1 ORF Clone (BC011005) - CDCS412298 from Creative biogene Species Human Accession P23528

Human CFL1 ORF Clone (BC018256) - CDCS412299 from Creative biogene Species Human Accession P23528

Human CFL1 cDNA Clone(NM_005507.2) - CDFH003524 from Creative biogene Species Human

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