| Gene Symbol |
DCSTAMP
|
| Entrez Gene |
81501
|
| Alt Symbol |
FIND, TM7SF4, hDC-STAMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dendrocyte expressed seven transmembrane protein
|
| Other Description |
DC-specific transmembrane protein|Dendritic cells (DC)-specific transmembrane protein|IL-4-induced protein|IL-Four (IL-4) induced|IL-Four INDuced|IL-four-induced protein|dendritic cell-specific transmembrane protein|dendrocyte-expressed seven transmembrane protein|transmembrane 7 superfamily member 4
|
| Swissprots |
E7ESG0 Q9H295 B7ZVW2 Q2M2D5
|
| Accessions |
CCO13835 EAW91892 Q9H295 AF277290 AAL02152 AF305068 AAG39167 AK095417 BAG53050 BC069349 AAH69349 BC112018 AAI12019 BC112020 AAI12021 BC171732 AAI71732 DA154308 XM_005251075 XP_005251132 XM_011517321 XP_011515623 XM_011517322 XP_011515624 XM_011517323 XP_011515625 XM_011517324 XP_011515626 NM_001257317 NP_001244246 NM_030788 NP_110415
|
| Function |
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes. {ECO:0000269|PubMed:11169400, ECO:0000269|PubMed:11345586}.
|