Gene Symbol | SULT1B1 |
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Entrez Gene | 27284 |
Alt Symbol | ST1B1, ST1B2, SULT1B2 |
Species | Human |
Gene Type | protein-coding |
Description | sulfotransferase family, cytosolic, 1B, member 1 |
Other Description | sulfotransferase 1B1|sulfotransferase 1B2|sulfotransferase family cytosolic 1B member 1|thyroid hormone sulfotransferase |
Swissprots | Q9UK34 Q96FI1 O43704 O15497 |
Accessions | AAF05917 EAX05595 O43704 BC010895 AAH10895 BG461453 D89479 BAA24547 U95726 AAB65154 XM_005265676 XP_005265733 XM_005265677 XP_005265734 XM_005265678 XP_005265735 XM_011531873 XP_011530175 NM_014465 NP_055280 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. {ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. {ECO:0000269|PubMed:9463486}. |
SULT1B1 CRISPR/Cas9 KO Plasmid (h) - sc-408645 from Santa Cruz Biotechnology
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SULT1B1 HDR Plasmid (h) - sc-408645-HDR from Santa Cruz Biotechnology
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SULT1B1 Double Nickase Plasmid (h) - sc-408645-NIC from Santa Cruz Biotechnology
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SULT1B1 Double Nickase Plasmid (h2) - sc-408645-NIC-2 from Santa Cruz Biotechnology
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SULT1B1 CRISPR Activation Plasmid (h) - sc-408645-ACT from Santa Cruz Biotechnology
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SULT1B1 CRISPR Activation Plasmid (h2) - sc-408645-ACT-2 from Santa Cruz Biotechnology
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SULT1B1 Lentiviral Activation Particles (h) - sc-408645-LAC from Santa Cruz Biotechnology
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SULT1B1 Lentiviral Activation Particles (h2) - sc-408645-LAC-2 from Santa Cruz Biotechnology
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SULT1B1 siRNA (h) - sc-89149 from Santa Cruz Biotechnology
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SULT1B1 shRNA Plasmid (h) - sc-89149-SH from Santa Cruz Biotechnology
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SULT1B1 shRNA (h) Lentiviral Particles - sc-89149-V from Santa Cruz Biotechnology
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Cytosolic Sulfotransferase 1B1/SULT1B1 RNAi - H00027284-R01 from Novus Biologicals
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MISSION® esiRNA - EHU119341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20819 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20819 from Sigma-Aldrich
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SULT1B1 siRNA (Human) - CRH9051 from Cohesion Biosciences
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SULT1B1 - MBS8237121 from MyBioSource
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shRNA set against Human SULT1B1 (NM_014465.3) - SHH420720 from Creative biogene
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Human SULT1B1 siRNA - orb269553 from Biorbyt
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SULT1B1 shRNA Plasmid (Human) - CHH9051 from Cohesion Biosciences
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SULT1B1 miRNA 3'UTR clone - MiUTR3H-10000 from Creative biogene
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