| Gene Symbol |
ERCC2
|
| Entrez Gene |
100125238
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 2
|
| Other Description |
CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex helicase XPD subunit|TFIIH basal transcription factor complex helicase subunit|excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)|excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2|xeroderma pigmentosum group D-complementing protein
|
| Swissprots |
A6QLJ0
|
| Accessions |
A6QLJ0 DAA19510 BC147982 AAI47983 BT029877 ABM06129 NM_001103317 NP_001096787
|
| Function |
ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
|
| Top Pathways |
Nucleotide excision repair, Basal transcription factors
|