| Gene Symbol | PNG1 |
|---|---|
| Entrez Gene | 835019 |
| Alt Symbol | AtPNG1, K6M13.12, K6M13_12, peptide-N-glycanase 1 |
| Species | Arabidopsis thaliana |
| Gene Type | protein-coding |
| Description | peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase |
| Other Description | - |
| Swissprots | Q9FGY9 Q84WJ1 |
| Accessions | AED95831 BAB10770 Q9FGY9 AK228156 BAF00112 AM745095 CAN87017 AY140065 AAM98206 BT003398 AAO30061 NM_124335 NP_199768 |
| Function | Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Top Pathways | Protein processing in endoplasmic reticulum |