ANKFY1

Gene Symbol	ANKFY1
Entrez Gene	51479
Alt Symbol	ANKHZN, BTBD23, ZFYVE14
Species	Human
Gene Type	protein-coding
Description	ankyrin repeat and FYVE domain containing 1
Other Description	Rabankyrin-5\|ankyrin repeat and FYVE domain-containing protein 1\|ankyrin repeat hooked to zinc finger motif\|ankyrin repeats hooked to a zinc finger motif\|rabankyrin-5\|rank-5
Swissprots	Q9ULG5 A8KA65 Q9P2R3 Q5RKV4
Accessions	EAW90448 EAW90449 EAW90450 Q9P2R3 AB033081 BAA86569 AB037360 BAA90300 AB073897 AK025483 AK025717 AK025960 AK057047 BAG51852 AK074324 AK091008 AK225170 AK292930 BAF85619 AK302712 BAG63933 AL706226 BC052308 AAH52308 BC060812 BC148355 AAI48356 BC152991 AAI52992 CR933717 CAI46247 DA856905 XM_005256679 XP_005256736 XM_011523926 XP_011522228 XM_011523927 XP_011522229 XM_011523928 XP_011522230 XM_011523929 XP_011522231 XM_011523930 XP_011522232 XM_011523931 XP_011522233 XM_011523932 XP_011522234 XM_011523933 XP_011522235 XR_934043 NM_001257999 NP_001244928 NM_016376 NP_057460 NR_047571 NM_020740
Function	Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extend in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the sucellular localization of the retromer complex in a EHD1- dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269\|PubMed:15328530, ECO:0000269\|PubMed:22284051, ECO:0000269\|PubMed:24102721}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:10940552}. Endosome membrane {ECO:0000269\|PubMed:10940552}; Peripheral membrane protein {ECO:0000269\|PubMed:10940552}. Early endosome {ECO:0000269\|PubMed:15328530}. Note=Also associated with endosomal membranes. Localizes to macropinosomes. {ECO:0000269\|PubMed:15328530}.
Tissue Specificity	High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain. {ECO:0000269\|PubMed:10574462, ECO:0000269\|PubMed:10940552}.

ANKFY1 (B-6) - sc-393353 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

ANKFY1 (B-6): sc-393353. Western blot analysis of ANKFY1 expression in MCF7 (A), T98G (B), HeLa (C) and Jurkat (D) whole cell lysates.

ANKFY1 (D-15) - sc-160136 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ANKFY1 (D-15): sc-160136. Western blot analysis of ANKFY1 expression in U-251-MG whole cell lysate (A) and mouse brain tissue extract (B).

ANKFY1 (H-300) - sc-367117 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ANKFY1 (Q-13) - sc-160137 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-ANKFY1 antibody - ab169273 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-ANKFY1 antibody (ab169273) at 1 µg/mlLane 1 : ANKFY1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-ANKFY1 antibody - ab102662 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 antibody (ab102662) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-ANKFY1 Antibody (aa436-465, Biotin) - LS-C232648 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465, AP) - LS-C232646 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465, FITC) - LS-C232649 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465, APC) - LS-C232650 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa429-469) - LS-C152223 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465, PE) - LS-C232652 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465, Azide-free, HRP) - LS-C249421 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody - LS-C306245 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa443-473) - LS-C319471 from LifeSpan Bioscience

Prices	$435.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ANKFY1 Antibody (aa436-465) - LS-C156338 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

ANKFY1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

ANKFY1 Antibody - NBP1-89085 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: ANKFY1 Antibody [NBP1-89085] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-35

ANKFY1 Antibody - NBP1-89084 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ANKFY1 Antibody - H00051479-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: ANKFY1 Antibody [H00051479-B01P] - Analysis of ANKFY1 expression in transfected 293T cell line by ANKFY1 polyclonal antibody. Lane 1: ANKFY1 transfected lysate(128.7 KDa). Lane 2: Non-transfected lysate.

Anti-ANKFY1 antibody produced in rabbit - HPA024522 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-ANKFY1: <B>Cat. No. HPA024522</B>: Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Anti-ANKFY1 antibody produced in mouse - SAB1401696 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Polyclonal Anti-ANKFY1, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401696</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-ANKFY1 antibody produced in rabbit - HPA024513 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-ANKFY1: <B>Cat. No. HPA024513</B>: Immunohistochemical staining of human kidney shows strong membranous positivity in tubular cells.

ANKFY1 Antibody - C-terminal region (ARP66715_P050) - ARP66715_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ANKFY1 Antibody - C-terminal region (OAAB02124) - OAAB02124 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

ANKFY1-Antibody-C-term - AP4704b from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

ANKFY1 Antibody (C-term) (Cat. #AP4704b) western blot analysis in MDA-MB435,CEM,MCF-7,Jurkat,Hela cell line lysates (35ug/lane).This demonstrates the ANKFY1 antibody detected the ANKFY1 protein (arrow).

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