PIK3CB

Gene Symbol	PIK3CB
Entrez Gene	5291
Alt Symbol	P110BETA, PI3K, PI3KBETA, PIK3C1
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other Description	PI3-kinase p110 subunit beta|PI3-kinase subunit beta|PI3K-beta|PtdIns-3-kinase p110|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphoinositide-3-kinase, catalytic, beta polypeptide|ptdIns-3-kinase subunit beta|ptdIns-3-kinase subunit p110-beta
Swissprots	D3DNF0 P42338 Q24JU2
Accessions	CAC21449 CAD20430 EAW79053 EAW79054 EAW79055 EAW79056 P42338 AI623206 AK293754 BAG57175 AK302937 BAG64095 BC003393 AAH03393 BC022049 AAH22049 BC033948 BC035432 BC045790 BC114432 AAI14433 CR749357 CAH18210 S67334 AAB29081 XM_005247530 XP_005247587 XM_006713659 XP_006713722 XM_011512895 XP_011511197 XM_011512896 XP_011511198 NM_001256045 NP_001242974 NM_006219 NP_006210
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI3 Kinase p110 beta + PI3 Kinase p85 beta full length protein - ab125571 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PI3K (p110 delta/p85 alpha) full length protein - ab125633 from Abcam Category Protein Prices $192.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human PI3 Kinase p110 beta protein fragment - ab159128 from Abcam Category Protein Source Wheat germ Species Human

PIK3CB Antibody Blocking Peptide - LS-E9429 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PI 3-Kinase p110 beta/PIK3CB Protein - H00005291-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIK3CB/p110beta Peptide - P2993 from Novus Biologicals Category Peptide Species Human

PI3KCB-Antibody-C-term-Blocking-Peptide - BP8017b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3K peptide - orb73135 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

PI3K protein - 30R-2878 from Fitzgerald Category Protein Prices $275.00 Sizes 5 µg Source Sf-9 insect cells Species Human

PIK3CB Blocking Peptide - 33R-9615 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human PIK3Cb Protein - abx068521 from Abbexa Category Protein Source E.coli Species Human

Human PIK3Cb Protein - abx068522 from Abbexa Category Protein Source E.coli Species Human

PIK3CB / PIK3C1 - H00005291-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIK3CB / PIK3C1 - H00005291-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIK3CB / PIK3C1 - P5669 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 20 µg Species Human

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb), Human - 20-9405 from ARP American Research Products Category Protein Prices $655.00 Sizes 50 µg Source E.coli Species Human

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb), Human - 20-9406 from ARP American Research Products Category Protein Prices $655.00 Sizes 50 µg Source E.coli Species Human

PIK3CB fusion protein - ag16456 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PIK3CB fusion protein - Ag17505 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PI3 kinase (p110b/p85a), Active Human Recombinant Protein - GWB-BEF413 from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

Recombinant Human PIK3CB/PIK3R1, His-tagged, Active - PIK3CB/PIK3R1-391H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human PIK3CB/PIK3R1, FLAG-tagged - PIK3CB/PIK3R1-632H from Creative Biomart Category Protein Source Sf9 cells .

Recombinant Human Human PIK3CB, His-tagged - PIK3CB-31095TH from Creative Biomart Category Protein

Recombinant Human Human PIK3CB, His-tagged - PIK3CB-31766TH from Creative Biomart Category Protein

Recombinant Human PIK3CB - PIK3CB-214H from Creative Biomart Category Protein Source Sf9 insect cells.

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