MYO7A

Gene Symbol MYO7A
Entrez Gene 4647
Alt Symbol DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B
Species Human
Gene Type protein-coding
Description myosin VIIA
Other Description myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))|unconventional myosin-VIIa
Swissprots Q92822 Q92821 P78427 Q13402 Q14785 B9A011 F8VUN5 Q13321
Accessions EAW75018 EAW75019 EAW75020 EAW75021 EAW75022 EAW75023 Q13402 AB209629 BAD92866 AB290181 BAG06735 BC023212 BC030215 BC144519 BC172349 AAI72349 BG108466 L29146 AAA20909 U34227 AAC50218 U39226 AAB03679 U55208 AAC50927 U55209 AAC50722 XM_005274012 XP_005274069 XM_006718558 XP_006718621 XM_006718559 XP_006718622 XM_006718560 XP_006718623 XM_006718561 XP_006718624 XM_011545044 XP_011543346 XM_011545045 XP_011543347 XM_011545046 XP_011543348 XM_011545047 XP_011543349 XM_011545048 XP_011543350 XM_011545049 XP_011543351 XM_011545050 XP_011543352 XM_011545051 XP_011543353 XM_011545052 XP_011543354 XR_949938 XR_949941 XR_949942 XR_949943 NM_000260 NP_000251 NM_001127179 NP_001120651 NM_001127180 NP_001120652
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000250, ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:214936
Subcellular Location Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin.
Tissue Specificity Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain. {ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21709241}.

Myosin VIIa (A-16) - sc-26709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Myosin VIIa (A-16): sc-26709. Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic localization.

Myosin VIIa (C-5) - sc-74516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Myosin VIIa (C-5): sc-74516. Western blot analysis of Myosin VIIa expression in Y79 whole cell lysate (A) and Y79 nuclear extract (B) and mouse testis tissue extract (C).

Myosin VIIa (H-60) - sc-25834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Myosin VIIa (H-60): sc-25834. Western blot analysis of Myosin VIIa expression in Y79 whole cell lysate (A) and Y79 nuclear extract (B).

Anti-Myosin VIIa antibody - ab3481 from Abcam

Prices $400.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot detection of Myosin VIIa in mouse testes tissue extract using ab3481.

Anti-Myosin VIIa antibody - ab92996 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Myosin VIIa antibody (ab92996) at 1 µg/ml + Testis (Mouse) Tissue Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Myosin VIIa antibody - ab191533 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Myosin VIIa antibody (ab191533)Lane 1 : SKOVCAR whole cell lysateLane 2 : HEK293T whole cell lysate

Anti-Myosin VIIa antibody [EPR7497] - ab150386 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7497
All lanes : Anti-Myosin VIIa antibody [EPR7497] (ab150386) at 1/1000 dilutionLane 1 : Y79 cell lysateLane 2 : rat testis cell lysateLane 3 : mouse testis cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat-anti rabbit antibody at 1/2000 dilution

Anti-Myosin VIIa antibody [EPR7498] - ab155984 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7498
Anti-Myosin VIIa antibody [EPR7498] (ab155984) at 1/1000 dilution + Y79 cell lysate at 10 µgSecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MYO7A / Myosin-VIIa Antibody (aa16-31) - LS-C121180 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYO7A / Myosin-VIIa Antibody - LS-C340997 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO7A / Myosin-VIIa Antibody (clone 1D3) - LS-C197737 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D3
Detection limit for recombinant GST tagged MYO7A is approximately 0.1 ng/ml as a capture antibody.

Anti-MYO7A / Myosin-VIIa Antibody - LS-C335379 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using MYO7A antibody.

Myosin VIIa Antibody - NBP1-84266 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Myosin VIIa Antibody [NBP1-84266] - Staining of human adrenal gland shows strong cytoplasmic and membranous positivity in cortical cells.

Myosin VIIa Antibody - H00004647-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Myosin VIIa Antibody [H00004647-A01] - Detection against Immunogen (36.67 KDa)

Myosin VIIa Antibody (1D3) - H00004647-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D3
Sandwich ELISA: Myosin VIIa Antibody (1D3) [H00004647-M01] - Detection limit for recombinant GST tagged MYO7A is approximately 0.1ng/ml as a capture antibody.

Myosin VIIa Polyclonal Antibody - bs-7761R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-Myosin VIIa Polyclonal Antibody, Unconjugated (bs-7761R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Monoclonal Anti-MYO7A antibody produced in mouse - WH0004647M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D3
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-MYO7A, <B>Cat. No. WH0004647M1</B>: the detection limit for recombinant GST tagged MYO7A is approximately 0.1ng/mL.

Anti-MYO7A antibody produced in rabbit - HPA028918 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MYO7A: <B>Cat. No. HPA028918</B>: Immunohistochemical staining of human adrenal gland shows strong cytoplasmic and membranous positivity in cortical cells.

MYO7A-Antibody-monoclonal-M01 - AT2960a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D3
Detection limit for recombinant GST tagged MYO7A is approximately 0.1ng/ml as a capture antibody.

Myosin VIIa antibody - GTX23481 from GeneTex

Prices $339.00
Sizes 200 μl
Host Rabbit
Clonality Polyclonal
Anti-Myosin VIIa antibody used in Western blot. GTX23481

Myosin VIIa antibody - GTX78219 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

Myosin VIIa antibody - orb100243 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of Myosin VIIa antibody

Rabbit anti-human myosin VIIA (OACA02363) - OACA02363 from Aviva Systems Biology

Prices $425.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

MYO7A antibody - 70R-18725 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

MYO7A Polyclonal Antibody - A3621 from ABclonal

Prices $200.00, $480.00
Sizes 50 µg, 200 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using MYO7A antibody.
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