Gene Symbol | G6PC |
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Entrez Gene | 2538 |
Alt Symbol | G6PC1, G6PT, GSD1, GSD1a |
Species | Human |
Gene Type | protein-coding |
Description | glucose-6-phosphatase, catalytic subunit |
Other Description | G-6-Pase|G6Pase|G6Pase-alpha|glucose-6-phosphatase|glucose-6-phosphatase alpha |
Swissprots | K7EL82 P35575 B4E1C3 A1L4C0 |
Accessions | AAD11621 CAA65638 EAW60901 EAW60902 P35575 AK303771 BAG64735 AK313982 BAG36695 AW614228 BC130478 AAI30479 BC136369 AAI36370 HQ258400 ADR83154 U01120 AAA16222 NM_000151 NP_000142 NM_001270397 NP_001257326 |
Function | Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Top Pathways | Glucagon signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, Carbohydrate digestion and absorption, Glycolysis / Gluconeogenesis |
G6Pase-α CRISPR/Cas9 KO Plasmid (h) - sc-417963 from Santa Cruz Biotechnology
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G6Pase-α HDR Plasmid (h) - sc-417963-HDR from Santa Cruz Biotechnology
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G6Pase-α Double Nickase Plasmid (h) - sc-417963-NIC from Santa Cruz Biotechnology
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G6Pase-α Double Nickase Plasmid (h2) - sc-417963-NIC-2 from Santa Cruz Biotechnology
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G6Pase-α CRISPR Activation Plasmid (h) - sc-417963-ACT from Santa Cruz Biotechnology
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G6Pase-α CRISPR Activation Plasmid (h2) - sc-417963-ACT-2 from Santa Cruz Biotechnology
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G6Pase-α Lentiviral Activation Particles (h) - sc-417963-LAC from Santa Cruz Biotechnology
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G6Pase-α Lentiviral Activation Particles (h2) - sc-417963-LAC-2 from Santa Cruz Biotechnology
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G6Pase-α siRNA (h) - sc-105380 from Santa Cruz Biotechnology
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G6Pase-α shRNA Plasmid (h) - sc-105380-SH from Santa Cruz Biotechnology
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G6Pase-α shRNA (h) Lentiviral Particles - sc-105380-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU004711 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0233 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0232 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0234 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9034 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9034 from Sigma-Aldrich
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G6PC siRNA (Human) - CRH1682 from Cohesion Biosciences
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G6PC RNAi - H00002538-R02 from Novus Biologicals
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G6PC - MBS8240390 from MyBioSource
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shRNA set against Human G6PC (NM_000151.3) - SHH298241 from Creative biogene
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G6PC shRNA Plasmid (Human) - CHH1682 from Cohesion Biosciences
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G6PC miRNA 3'UTR clone - MiUTR3H-13029 from Creative biogene
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