| Gene Symbol |
NPTN
|
| Entrez Gene |
27020
|
| Alt Symbol |
GP55, GP65, SDFR1, SDR1, np55, np65
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuroplastin
|
| Other Description |
SDR-1|stromal cell derived factor receptor 1|stromal cell-derived receptor 1
|
| Swissprots |
Q6NVX7 B2RAL7 Q9Y639 Q17R52 B7Z4D3 B7ZLL2 Q59EJ9 Q9Y640
|
| Accessions |
EAW77930 EAW77931 EAW77932 Q9Y639 AB209812 BAD93049 AF035287 AAB88179 AF109126 AAD43217 AF109127 AAD43218 AI357728 AK129908 AK297184 BAH12519 AK304478 BAH14196 AK313441 AK314248 BAG36914 AL117411 CAB55909 BC030773 BC067828 BC105979 AAI05980 BC117462 AAI17463 BC143880 AAI43881 BC143881 AAI43882 CN357076 CR936779 HQ258139 ADR82893 XM_011521452 XP_011519754 XR_931793 XR_931794 NM_001161363 NP_001154835 NM_001161364 NP_001154836 NM_012428 NP_036560 NM_017455 NP_059429
|
| Function |
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Enriched at postsynaptic density. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level). {ECO:0000269|PubMed:17196182, ECO:0000269|Ref.1}.
|
![Western Blot: NPTN Overexpression Lysate (Adult Normal) [NBL1-13758] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NPTN.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7253_NPTN%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13758-img0002.jpg)