Gene Symbol | DIG1 |
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Entrez Gene | 856058 |
Alt Symbol | RST1 |
Species | Yeast |
Gene Type | protein-coding |
Description | Dig1p |
Other Description | - |
Swissprots | Q03063 D6W3W5 |
Accessions | DAA11381 Q03063 NM_001183863 NP_015276 |
Function | DIG1 and DIG2 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein- protein interaction. DIG1 colocalizes to promoters with STE12 and redistributes with it during induction of filamentation (by butanol) or mating (by pheromone) to program specific genes, but binding of DIG1 to STE12 is reduced by pheromone treatment. {ECO:0000269|PubMed:10825185, ECO:0000269|PubMed:12410840, ECO:0000269|PubMed:12732146, ECO:0000269|PubMed:8918885, ECO:0000269|PubMed:9094309, ECO:0000269|PubMed:9744865, ECO:0000269|PubMed:9860980}. |
Subcellular Location | Nucleus. |
Top Pathways | MAPK signaling pathway - yeast |
Recombinant Saccharomyces cerevisiae Down-regulator of invasive growth 1(DIG1) - CSB-YP311738SVG CSB-EP311738SVG CSB-BP311738SVG CSB-MP311738SVG from Cusabio
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Down-regulator of invasive growth 1 (DIG1), Recombinant Protein - MBS1141174 from MyBioSource
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