PTP4A2
| Gene Symbol | PTP4A2 |
|---|---|
| Entrez Gene | 8073 |
| Alt Symbol | HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase type IVA, member 2 |
| Other Description | PTP(CAAXII)|phosphatase of regenerating liver 2|protein tyrosine phosphatase IVA|protein tyrosine phosphatase IVA2|protein tyrosine phosphatase type IVA 2|protein-tyrosine phosphatase 4a2|protein-tyrosine phosphatase of regenerating liver 2 |
| Swissprots | O00649 R4GN50 Q15260 Q12974 Q15197 Q15261 B4DM39 D3DPP0 Q15259 A8K9I8 E9PGJ6 |
| Accessions | AAB39331 AAB42169 AAB42170 EAX07578 EAX07579 EAX07580 EAX07581 EAX07582 EAX07583 EAX07584 Q12974 AF208850 AAF64264 AK129578 AK292703 BAF85392 AK297280 BAG59751 AM392609 CAL37487 AM393532 CAL38409 AM393556 CAL38433 BC018662 BC070181 BC070182 AAH70182 BI545293 BI552091 BM996809 L39000 AAB59575 N21082 U14603 AAA90979 U48297 AAB40598 XM_005271229 XP_005271286 XM_005271230 XP_005271287 XM_005271231 XP_005271288 XM_005271232 XP_005271289 XM_006710927 XP_006710990 XM_006710928 XP_006710991 XR_946766 NM_001195100 NP_001182029 NM_001195101 NP_001182030 NM_080391 NP_536316 NM_003479 NM_080392 |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:14643450}. |
| Subcellular Location | Cell membrane. Early endosome. Cytoplasm. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:11734337, ECO:0000269|PubMed:8661118}. |
PRL-2 CRISPR/Cas9 KO Plasmid (h) - sc-418059 from Santa Cruz Biotechnology
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PRL-2 HDR Plasmid (h) - sc-418059-HDR from Santa Cruz Biotechnology
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PRL-2 Double Nickase Plasmid (h) - sc-418059-NIC from Santa Cruz Biotechnology
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PRL-2 Double Nickase Plasmid (h2) - sc-418059-NIC-2 from Santa Cruz Biotechnology
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PRL-2 CRISPR Activation Plasmid (h) - sc-418059-ACT from Santa Cruz Biotechnology
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PRL-2 CRISPR Activation Plasmid (h2) - sc-418059-ACT-2 from Santa Cruz Biotechnology
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PRL-2 Lentiviral Activation Particles (h) - sc-418059-LAC from Santa Cruz Biotechnology
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PRL-2 Lentiviral Activation Particles (h2) - sc-418059-LAC-2 from Santa Cruz Biotechnology
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PRL-2 siRNA (h) - sc-106449 from Santa Cruz Biotechnology
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PRL-2 shRNA Plasmid (h) - sc-106449-SH from Santa Cruz Biotechnology
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PRL-2 shRNA (h) Lentiviral Particles - sc-106449-V from Santa Cruz Biotechnology
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PRL-2/PTP4A2 RNAi - H00008073-R02 from Novus Biologicals
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PRL-2/PTP4A2 RNAi - H00008073-R01 from Novus Biologicals
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MISSION® esiRNA - EHU071041 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0701 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0700 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1052 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0702 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1053 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17688 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17688 from Sigma-Aldrich
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PTP4A2 siRNA (Human) - CRH5356 from Cohesion Biosciences
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PRL-2/PTP4A2 RNAi - H00008073-R03 from Novus Biologicals
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shRNA set against Human Ptp4a2 (NM_080391.3) - SHH386328 from Creative biogene
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