AIRE

Gene Symbol	AIRE
Entrez Gene	326
Alt Symbol	AIRE1, APECED, APS1, APSI, PGA1
Species	Human
Gene Type	protein-coding
Description	autoimmune regulator
Other Description	autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
Swissprots	O43922 O75745 B2RP50 O43932 O43918
Accessions	BAA23990 BAA23991 BAA23992 BAA95560 BAF62470 CAA08759 EAX09441 EAX09443 O43918 AB006682 BAA23988 AB006683 BAA23989 AB006685 BAA23993 AK309572 BC137268 AAI37269 BC137270 AAI37271 BC142608 Z97990 CAB10790 XM_011529551 XP_011527853 NM_000383 NP_000374 NM_000658 NM_000659
Function	Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. {ECO:0000250, ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:18292755}.
Subcellular Location	Nucleus. Cytoplasm. Note=Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm.
Tissue Specificity	Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Top Pathways	Ubiquitin mediated proteolysis, Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human AIRE ELISA Kit (Sandwich ELISA) - LS-F6679 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Mouse AIRE ELISA Kit (Sandwich ELISA) - LS-F7133 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Human Phospho-AIRE (Ser156) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1721 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human AIRE ELISA Kit (Cell-Based ELISA) - LS-F1786 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human AIRE ELISA Kit (Sandwich ELISA) - LS-F10777 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human Autoimmune Regulator ELISA Kit - abx150773 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Autoimmune Regulator, AIRE, Human, ELISA Kit - E-EL-H0536 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Autoimmune Regulator (AIRE), Human, ELISA Kit - SEC322Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

Autoimmune regulator, AIRE, Human, ELISA Kit - E13302h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Autoimmune Regulator, Human, ELISA Kit - E01A0527 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1 ng/mL Range 0-10 ng/mL

Autoimmune Regulator, AIRE, Rabbit, ELISA Kit - E-EL-RB1803 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Autoimmune Regulator, AIRE, Chicken, ELISA Kit - E-EL-Ch2025 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Autoimmune Regulator, AIRE, Porcine, ELISA Kit - E-EL-P1136 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Autoimmune Regulator, AIRE, Guinea Pig, ELISA Kit - E-EL-GP0749 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Autoimmune Regulator, AIRE, Monkey, ELISA Kit - E-EL-MK1750 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human AIRE ELISA Kit - HA0534 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine AIRE ELISA Kit - AA0534 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

AIRE Colorimetric Cell-Based ELISA Kit - CB5027 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

AIRE (Phospho-Ser156) Colorimetric Cell-Based ELISA Kit - CBP1805 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human AIRE(Autoimmune Regulator) ELISA Kit - E-EL-H0536 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human AIRE (Autoimmune Regulator) CLIA Kit - E-CL-H0428 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

AIRE, ELISA Kit - MBS2501968 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

AIRE, ELISA Kit - MBS2515027 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

AIRE, ELISA Kit - MBS2514310 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

AIRE, ELISA Kit - MBS2514570 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

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