| Gene Symbol |
TKTL2
|
| Entrez Gene |
84076
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transketolase-like 2
|
| Other Description |
transketolase-like protein 2
|
| Swissprots |
Q96M82 A4FVB4 Q8NCT0 Q9H0I9
|
| Accessions |
CBH19264 EAX04838 Q9H0I9 AK057325 BAB71427 AK057537 BAB71524 AK098582 AK314517 BAG37115 AL136779 CAB66713 AL834334 CAD39002 AM393077 CAL37955 BC028707 AAH28707 BC125101 AAI25102 BC142943 AAI42944 BC143053 AAI43054 BC143054 AAI43055 BC146698 AAI46699 CR533560 CAG38591 DB095901 NM_032136 NP_115512
|
| Function |
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. {ECO:0000269|PubMed:17321041}.
|
| Tissue Specificity |
Overexpressed in hepatoma cancer cells. {ECO:0000269|PubMed:17321041}.
|
| Top Pathways |
Pentose phosphate pathway, Biosynthesis of amino acids, Carbon metabolism
|