SARAF

Gene Symbol SARAF
Entrez Gene 51669
Alt Symbol FOAP-7, HSPC035, TMEM66, XTP3
Species Human
Gene Type protein-coding
Description store-operated calcium entry-associated regulatory factor
Other Description HBV X-transactivated gene 3 protein|HBV XAg-transactivated protein 3|SARAF long isoform|SARAF short isoform|SOCE-associated regulatory factor|transmembrane protein 66
Swissprots H9MHJ9 Q53HE8 Q9Y683 D3DSU7 B7Z9J1 Q9UNZ3 B3KQQ4 H9MHJ8 Q96BY9
Accessions CAH05318 CAH05373 EAW63471 EAW63472 EAW63473 EAW63474 Q96BY9 AB028926 BAB82465 AF078855 AAD44487 AF100748 AAD43012 AF490252 AAO85460 AK025927 AK075340 BAG52116 AK094386 BAG52863 AK130057 AK222632 BAD96352 AK295360 BAH12043 AK314659 AK315956 BAH14327 AY359104 AAQ89462 AY454545 BC015012 AAH15012 BM280420 DC359554 DQ892451 ABM83377 DQ895663 ABM86589 JQ348891 AEZ06361 JQ348892 AEZ06362 Z70223 NM_001284239 NP_001271168 NM_016127 NP_057211
Function Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269|PubMed:22464749}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1- dependent manner following cytosolic Ca(2+) elevation.
Tissue Specificity Highly expressed in macrophages. {ECO:0000269|Ref.2}.

TMEM66-Over-expression-Lysate - LY14829a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TMEM66 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TMEM66 gene.

TMEM66 293 Cell Lysate - 406806 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

TMEM66 Overexpression Lysate (Native) - NBL1-17098 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TMEM66 Overexpression Lysate (Adult Normal) [NBL1-17098] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TMEM66.

TMEM66 Over-expression Lysate Product - GWB-D9518B from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human TMEM66 Knockdown Stable Cell Line - CSC-DC016267 from Creative biogene

Category Cell Line
Species Human
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