| Gene Symbol |
CANT1
|
| Entrez Gene |
124583
|
| Alt Symbol |
DBQD, SCAN-1, SCAN1, SHAPY
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium activated nucleotidase 1
|
| Other Description |
Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase|apyrase homolog|micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification|putative MAPK-activating protein PM09|putative NF-kappa-B-activating protein 107|soluble Ca-activated nucleotidase, isozyme 1|soluble calcium-activated nucleotidase 1|soluble calcium-activated nucleotidase SCAN-1
|
| Swissprots |
Q8NG05 Q8NHP0 Q7Z2J7 B4DJ54 Q9BSD5 Q8WVQ1
|
| Accessions |
CAF86751 EAW89548 EAW89549 EAW89550 EAW89551 EAW89552 EAW89553 EAW89554 EAW89555 Q8WVQ1 AB097006 BAC77359 AB097033 BAC77386 AF328554 AAM94564 AJ312208 CAC85468 AK026161 AK074687 BAC11139 AK295930 BAG58716 BC005104 AAH05104 BC017655 AAH17655 BC065038 AAH65038 BC118563 DC355691 DQ578890 DQ582927 DQ585977 DQ595190 XM_005257020 XP_005257077 XM_005257021 XP_005257078 XM_005257022 XP_005257079 XM_006721683 XP_006721746 XM_011524291 XP_011522593 XM_011524292 XP_011522594 XM_011524293 XP_011522595 XM_011524294 XP_011522596 XM_011524295 XP_011522597 NM_001159772 NP_001153244 NM_001159773 NP_001153245 NM_138793 NP_620148
|
| Function |
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. {ECO:0000269|PubMed:12234496, ECO:0000269|PubMed:15248776, ECO:0000269|PubMed:22539336}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12234496}; Single-pass type II membrane protein {ECO:0000269|PubMed:12234496}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12234496}; Single-pass type II membrane protein {ECO:0000269|PubMed:12234496}. Note=Processed form: Secreted.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12234496}.
|
| Top Pathways |
Purine metabolism, Pyrimidine metabolism
|
