| Gene Symbol |
RAB11FIP3
|
| Entrez Gene |
9727
|
| Alt Symbol |
CART1, Rab11-FIP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB11 family interacting protein 3 (class II)
|
| Other Description |
EF hands-containing Rab-interacting protein|FIP3-Rab11|MU-MB-17.148|PAC196A12.1|arfophilin-1|cytoplasmic adaptor for RAR and TR|eferin|rab11 family-interacting protein 3|rab11-family interacting protein 3
|
| Swissprots |
B0QYI8 Q9NUI0 B1AHQ0 B0QYT8 Q4VXV7 Q9H1G0 Q9H155 O75154 B4DZR6 B4DEI7 Q7Z5E9
|
| Accessions |
AAK61232 EAW85805 EAW85806 EAW85807 EAW85808 EAW85809 EAW85810 O75154 AB014565 BAA31640 AF038180 AF395731 AAL12940 AK293644 BAG57098 AK303061 BAG64178 AY130007 AAN05091 BC051360 AAH51360 DC395000 DC404361 XM_005255713 XP_005255770 XM_005255714 XP_005255771 XM_005255715 XP_005255772 XM_005255717 XP_005255774 XM_005255718 XP_005255775 XM_006725242 XP_006725305 XM_006725245 XP_006725308 XM_006725246 XP_006725309 XM_006725247 XP_006725310 XM_006725248 XP_006725311 XM_011522764 XP_011521066 XM_011522765 XP_011521067 XM_011546751 XP_011545053 XM_011546752 XP_011545054 XR_932981 XR_951936 NM_001142272 NP_001135744 NM_014700 NP_055515
|
| Function |
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:19327867}.
|
| Subcellular Location |
Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody.
|
| Top Pathways |
Endocytosis
|