| Gene Symbol |
SLC7A5
|
| Entrez Gene |
8140
|
| Alt Symbol |
4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 7 (amino acid transporter light chain, L system), member 5
|
| Other Description |
4F2 LC|4F2 light chain|CD98 light chain|L-type amino acid transporter 1|integral membrane protein E16|large neutral amino acids transporter 1|large neutral amino acids transporter small subunit 1|sodium-independent neutral amino acid transporter LAT1|solute carrier family 7 (cationic amino acid transporter, y+ system), member 5|solute carrier family 7 member 5|y+ system cationic amino acid transporter
|
| Swissprots |
Q9UQC0 Q9UBN8 Q8IV97 Q9UP15 Q01650
|
| Accessions |
BAB70708 CAJ58680 EAW95373 EAW95374 EAW95375 Q01650 AB017908 BAA75746 AB018009 BAA84648 AB018542 BAA33851 AF077866 AAC61479 AF104032 AAD20464 BC014177 BC039692 AAH39692 BC042600 AAH42600 BC114608 DQ893338 ABM84264 DQ896766 ABM87765 M80244 AAA35780 XM_006721286 XP_006721349 XM_011523354 XP_011521656 XM_011523355 XP_011521657 NM_003486 NP_003477
|
| Function |
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn
|
| Subcellular Location |
Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. {ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10072483, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12824232, ECO:0000269|PubMed:1597461, ECO:0000269|PubMed:16027961, ECO:0000269|PubMed:16496379}.
|
| Top Pathways |
Central carbon metabolism in cancer
|