| Gene Symbol |
Ctcf
|
| Entrez Gene |
83726
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
CCCTC-binding factor (zinc finger protein)
|
| Other Description |
11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF
|
| Swissprots |
Q9R1D1
|
| Accessions |
EDL92388 EDL92389 Q9R1D1 AF133731 AAD27869 FQ227933 FQ228237 XM_006255536 XP_006255598 XM_008772536 XP_008770758 XM_008772537 XP_008770759 XM_008772538 XP_008770760 XM_008772539 XP_008770761 NM_031824 NP_114012
|
| Function |
Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase (By similarity). {ECO:0000250}.
|